Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C3AR1 | Q16581 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.39 |
| ▸ | NPC1 | O15118 | 5/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2909910 | 0.90 | C3AR1 (0.40) | C3AR1KMT2ANPC1RAB9AHTT | |
| SCHEMBL2909849 | 0.85 | NPC1 (0.46) | KMT2ANPC1RAB9AALDH1A1LMNA | |
| SCHEMBL3654059 | 0.81 | EPHX1 (0.44) | C3AR1KMT2ANPC1RAB9AHPGD | |
| SCHEMBL2907586 | 0.80 | EPHX1 (0.41) | KMT2ANPC1RAB9AHPGDALDH1A1 | |
| SCHEMBL2912657 | 0.80 | EPHX2 (0.51) | KMT2ANPC1RAB9AHPGDLMNA | |
| SCHEMBL2912992 | 0.80 | NPC1 (0.45) | KMT2ANPC1RAB9AALDH1A1LMNA | |
| SCHEMBL3650434 | 0.80 | KMT2A (0.41) | KMT2ANPC1RAB9AALDH1A1LMNA | |
| SCHEMBL3652035 | 0.79 | EPHX2 (0.47) | KMT2ANPC1RAB9AHPGDALDH1A1 | |
| SCHEMBL2912844 | 0.78 | LMNA (0.49) | KMT2ANPC1RAB9AHTTKDM4E | |
| SCHEMBL2915607 | 0.78 | EPHX1 (0.48) | KMT2ANPC1RAB9AHTTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222645-A2 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS FXR AGONISTS | F. Hoffmann-La Roche AG (CH) | 2010-09-01 | — | — | EP | claimed |
| WO-2009062874-A2 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS FXR AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-05-22 | — | — | WO | claimed |
| EP-2222645-A2 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS FXR AGONISTS | F. Hoffmann-La Roche AG (CH) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009062874-A2 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS FXR AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-05-22 | — | — | WO | disclosed |