Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 2/20 | 0.49 |
| ▸ | PRKCI | P41743 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.33 |
| ▸ | SYK | P43405 | 3/20 | 0.32 |
| ▸ | AXL | P30530 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30055673 | 1.00 | DAO (0.49) | DAOPRKCIPDE3BPDE3ASYK | |
| SCHEMBL3631219 | 0.79 | PDE3B (0.40) | PDE3BPDE3ASYKAURKA | |
| SCHEMBL23074721 | 0.78 | DAO (0.33) | DAOPDE3BPDE3ASYKAURKA | |
| SCHEMBL958365 | 0.78 | DAO (0.33) | DAOPDE3BPDE3ASYKAURKA | |
| SCHEMBL10298658 | 0.75 | PDE3B (0.35) | DAOPDE3BPDE3ASYK | |
| SCHEMBL12615432 | 0.74 | AURKA (0.37) | DAOPDE3BPDE3ASYKAURKA | |
| SCHEMBL12946990 | 0.74 | PDE3B (0.33) | DAOPDE3BPDE3ASYK | |
| SCHEMBL4458348 | 0.67 | AURKA (0.54) | AURKA | |
| SCHEMBL16919115 | 0.66 | GFER (0.38) | PDE3BPDE3AAURKAHTT | |
| SCHEMBL341634 | 0.66 | NOS1 (0.37) | DAOPDE3BPDE3ASYKAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240239794-A1 | PKC-Theta Modulators | EXSCIENTIA AI LIMITED (GB) | 2024-07-18 | — | — | US | disclosed |
| CN-117355522-A | PKC-theta modulators | 爱智药人工智能有限公司 | 2024-01-05 | — | — | CN | disclosed |
| CN-117295738-A | PKC-theta modulators | 爱智药人工智能有限公司 | 2023-12-26 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240239794-A1 | PKC-Theta Modulators | PRKCQ, PRKCH, PRKCZ | DAO 3203/4885PRKCI 8/4885PDE3B 207/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.