Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.43 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.42 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.42 |
| ▸ | ITGAL | P20701 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CRHBP | P24387 | 2/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CTSB | P07858 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12472476 | 0.75 | PKM (0.37) | KMT2APOLBLMNAGAAL3MBTL1 | |
| SCHEMBL301140 | 0.72 | SMN1; SMN2 (0.50) | NOTUMKMT2ASMN1; SMN2L3MBTL1 | |
| SCHEMBL9228795 | 0.72 | NOTUM (0.49) | NOTUMPDK1ITGB2ICAM1ITGAL | |
| SCHEMBL5636846 | 0.72 | ITGB2 (0.48) | NOTUMPDK1ITGB2ICAM1ITGAL | |
| SCHEMBL7345437 | 0.71 | POLB (0.58) | NOTUMKMT2APOLBSMN1; SMN2LMNA | |
| SCHEMBL29877196 | 0.71 | NOTUM (0.45) | NOTUMPDK1ITGB2ICAM1ITGAL | |
| SCHEMBL5636855 | 0.71 | NOTUM (0.45) | NOTUMPDK1ITGB2ICAM1ITGAL | |
| SCHEMBL21455717 | 0.71 | NOTUM (0.45) | NOTUMPDK1ITGB2ICAM1ITGAL | |
| Hydrochloric Acid SCHEMBL11437417 | 0.70 | ITGB2 (0.46) | NOTUMPDK1ITGB2ICAM1ITGAL | |
| SCHEMBL19859267 | 0.69 | NOTUM (0.58) | NOTUMPDK1KMT2AHDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |