Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ethambutol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.77 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.77 |
| ▸ | CNR1 | P21554 | 1/20 | 0.77 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.77 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethambutol SCHEMBL8575513 | 1.00 | LMNA (0.77) | LMNATDP1CNR1ADRA1AKDM4E | |
| Ethambutol SCHEMBL2342754 | 0.93 | LMNA (0.81) | LMNATDP1CNR1ADRA1AKDM4E | |
| Acetic Acid SCHEMBL11209914 | 0.91 | LMNA (0.64) | LMNATDP1CNR1ADRA1AKDM4E | |
| Ethambutol SCHEMBL9906602 | 0.88 | LMNA (1.00) | LMNATDP1CNR1ADRA1AKDM4E | |
| Ethambutol SCHEMBL15479016 | 0.88 | LMNA (1.00) | LMNATDP1CNR1ADRA1AKDM4E | |
| Ethambutol SCHEMBL4029 | 0.88 | LMNA (1.00) | LMNATDP1CNR1ADRA1AKDM4E | |
| Ethambutol SCHEMBL3399 | 0.88 | LMNA (1.00) | LMNATDP1CNR1ADRA1AKDM4E | |
| Ethambutol SCHEMBL2636850 | 0.88 | LMNA (1.00) | LMNATDP1CNR1ADRA1AKDM4E | |
| Ethambutol SCHEMBL2961583 | 0.88 | LMNA (1.00) | LMNATDP1CNR1ADRA1AKDM4E | |
| Ethambutol SCHEMBL2319449 | 0.87 | LMNA (0.71) | LMNATDP1CNR1ADRA1AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117295399-A | Novel microparticles containing active substances | 巴斯夫欧洲公司 | 2023-12-26 | — | — | CN | disclosed |
| CN-117241879-A | Novel microcapsules containing active substances | 巴斯夫欧洲公司 | 2023-12-15 | — | — | CN | disclosed |
| CN-116568312-A | Stable semi-solid chewable gel compositions and methods of making and using the same | 西雅图咖米公司 | 2023-08-08 | — | — | CN | disclosed |