Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ethambutol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.71 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.71 |
| ▸ | CNR1 | P21554 | 1/20 | 0.71 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.71 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.42 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.42 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP8 | P22894 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethambutol SCHEMBL8575513 | 0.87 | LMNA (0.77) | LMNATDP1CNR1ADRA1AKDM4E | |
| Ethambutol SCHEMBL29131237 | 0.87 | LMNA (0.77) | LMNATDP1CNR1ADRA1AKDM4E | |
| Ethambutol SCHEMBL29157717 | 0.87 | LMNA (0.85) | LMNATDP1CNR1ADRA1AKDM4E | |
| Ethambutol SCHEMBL8736108 | 0.86 | LMNA (0.68) | LMNATDP1CNR1ADRA1AKDM4E | |
| Ethambutol SCHEMBL2342754 | 0.85 | LMNA (0.81) | LMNATDP1CNR1ADRA1AKDM4E | |
| Ethambutol SCHEMBL2961583 | 0.84 | LMNA (1.00) | LMNATDP1CNR1ADRA1AKDM4E | |
| Ethambutol SCHEMBL4029 | 0.84 | LMNA (1.00) | LMNATDP1CNR1ADRA1AKDM4E | |
| Ethambutol SCHEMBL3399 | 0.84 | LMNA (1.00) | LMNATDP1CNR1ADRA1AKDM4E | |
| Ethambutol SCHEMBL15479016 | 0.84 | LMNA (1.00) | LMNATDP1CNR1ADRA1AKDM4E | |
| Ethambutol SCHEMBL2636850 | 0.84 | LMNA (1.00) | LMNATDP1CNR1ADRA1AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3362071-A1 | CRYSTALLIZATION METHOD AND BIOAVAILABILITY | Grünenthal GmbH (DE) | 2018-08-22 | — | — | EP | disclosed |
| WO-2017049294-A1 | CRYSTALLIZATION METHOD AND BIOAVAILABILITY | THAR PHARMACEUTICALS, INC. (US) | 2017-03-23 | — | — | WO | disclosed |
| WO-2011097269-A9 | CRYSTALLIZATION METHOD AND BIOAVAILABILITY | THAR PHARMACEUTICALS, INC. (US) | 2012-12-27 | — | — | WO | disclosed |
| EP-2531200-A1 | CRYSTALLIZATION METHOD AND BIOAVAILABILITY | Thar Pharmaceuticals, Inc. (US) | 2012-12-12 | — | — | EP | disclosed |
| WO-2011097269-A1 | CRYSTALLIZATION METHOD AND BIOAVAILABILITY | THAR PHARMACEUTICALS, INC. (US) | 2011-08-11 | — | — | WO | disclosed |