Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.54 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.51 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.51 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.43 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.43 |
| ▸ | KCNQ5 | Q9NR82 | 2/20 | 0.43 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.43 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.43 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30716415 | 0.86 | GRM5 (0.48) | GRM5CYP11B2CYP11B1MAPK7ABL1 | |
| SCHEMBL29131446 | 0.86 | GRM5 (0.48) | GRM5CYP11B2CYP11B1MAPK7ABL1 | |
| SCHEMBL30998138 | 0.82 | CYP11B2 (0.77) | CYP11B2CYP11B1NPC1KMT2AALDH1A1 | |
| SCHEMBL30716396 | 0.78 | RIPK2 (0.48) | GRM5CYP11B2CYP11B1PPARGNPC1 | |
| SCHEMBL29435928 | 0.78 | CYP11B2 (0.42) | GRM5CYP11B2CYP11B1PPARGNPC1 | |
| SCHEMBL22203184 | 0.78 | CYP11B2 (0.42) | GRM5CYP11B2CYP11B1PPARGNPC1 | |
| SCHEMBL10516505 | 0.75 | JAK2 (0.70) | GRM5CYP11B2NPC1RAB9AGPR27 | |
| Hydrochloric Acid SCHEMBL10680065 | 0.74 | JAK2 (0.68) | GRM5CYP11B2NPC1RAB9AGPR27 | |
| SCHEMBL10680062 | 0.73 | JAK2 (0.51) | GRM5CYP11B2MAPK7BCAT2GPR27 | |
| SCHEMBL29131424 | 0.72 | ABL1 (0.54) | ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260022100-A1 | NAV1.8 INHIBITOR | Wuhan Humanwell Innovative Drug Research and Development Center Limited Company (CN) | 2026-01-22 | — | — | US | disclosed |
| EP-4545517-A1 | NAV1.8 INHIBITOR | Wuhan Humanwell Innovative Drug Research and Development Center Limited Company (CN) | 2025-04-30 | — | — | EP | disclosed |
| CN-117263856-A | Nav1.8 inhibitors | 武汉人福创新药物研发中心有限公司 | 2023-12-22 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260022100-A1 | NAV1.8 INHIBITOR | SCN8A, SCN1B, SCN1A | GRM5 595/4885CYP11B2 675/4885CYP11B1 484/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.