Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.36 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.36 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6472112 | 0.84 | HDAC4 (0.45) | HDAC4PDE4DGAAKDM4EALDH1A1 | |
| SCHEMBL18742726 | 0.73 | HDAC4 (0.63) | HDAC4GAAHDAC3HDAC1HDAC2 | |
| SCHEMBL29661878 | 0.71 | HDAC4 (0.60) | HDAC4GAAHDAC3HDAC1HDAC2 | |
| SCHEMBL5342025 | 0.71 | HDAC4 (0.60) | HDAC4GAAHDAC3HDAC1HDAC2 | |
| SCHEMBL14232917 | 0.70 | HDAC4 (0.46) | HDAC4GAA | |
| SCHEMBL2435589 | 0.70 | KDM4E (0.43) | KDM4EALDH1A1 | |
| SCHEMBL6597123 | 0.69 | SLC6A2 (0.41) | ALDH1A1 | |
| SCHEMBL2913178 | 0.69 | GAA (0.44) | HDAC4GAATDP1KDM4EALDH1A1 | |
| SCHEMBL9330906 | 0.68 | AKR1C1 (0.50) | HDAC4 | |
| SCHEMBL9386533 | 0.68 | RXRA (0.36) | HDAC4GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2214487-A1 | NOVEL SEH INHIBITORS AND THEIR USE | GlaxoSmithKline LLC (US) | 2010-08-11 | — | — | EP | disclosed |
| WO-2009049157-A1 | NOVEL SEH INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-04-16 | — | — | WO | disclosed |