Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | RBP4 | P02753 | 8/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6472117 | 0.81 | GAA (0.41) | GAATDP1RBP4HDAC4HTR2C | |
| SCHEMBL5906965 | 0.79 | CETP (0.40) | GAAHPGDMAPK1CYP3A4MAPT | |
| SCHEMBL4991857 | 0.74 | GAA (0.46) | GAATDP1RBP4HDAC4HTR2C | |
| SCHEMBL32690457 | 0.72 | KDM1A (0.44) | CYP3A4 | |
| SCHEMBL2437373 | 0.70 | KDM4E (0.43) | KDM4EALDH1A1MEN1CYP3A4CYP2C9 | |
| SCHEMBL2913172 | 0.69 | HDAC4 (0.48) | GAATDP1HDAC4KDM4EALDH1A1 | |
| SCHEMBL6472112 | 0.67 | HDAC4 (0.45) | GAAHDAC4KDM4EALDH1A1MAPK1 | |
| SCHEMBL2431727 | 0.66 | PDK1 (0.32) | MAPK1CYP3A4CYP2D6 | |
| SCHEMBL29399304 | 0.66 | RBP4 (0.38) | GAATDP1RBP4HTR2CKDM4E | |
| SCHEMBL5695498 | 0.66 | GAA (0.42) | GAATDP1RBP4HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2214487-A1 | NOVEL SEH INHIBITORS AND THEIR USE | GlaxoSmithKline LLC (US) | 2010-08-11 | — | — | EP | disclosed |
| WO-2009049157-A1 | NOVEL SEH INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-04-16 | — | — | WO | disclosed |