Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.41 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.62 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.62 |
| ▸ | TSHR | P16473 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | PNMT | P11086 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | BLM | P54132 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7677412 | 0.98 | GABRA1 (0.65) | GABRA1GABRB2TSHRPOLBCYP3A4 | |
| SCHEMBL633569 | 0.98 | GABRA1 (0.65) | GABRA1GABRB2TSHRPOLBCYP3A4 | |
| SCHEMBL7675674 | 0.98 | GABRA1 (0.65) | GABRA1GABRB2TSHRPOLBCYP3A4 | |
| Hydrochloric Acid SCHEMBL9460866 | 0.95 | GABRA1 (0.62) | GABRA1GABRB2TSHRPOLBCYP3A4 | |
| SCHEMBL11406743 | 0.82 | GABRA1 (0.58) | GABRA1GABRB2TSHRPOLBCYP3A4 | |
| SCHEMBL135746 | 0.79 | LMNA (0.50) | GABRA1GABRB2TSHRCYP3A4NFKB1 | |
| SCHEMBL30678522 | 0.79 | CYP2D6 (0.54) | GABRA1GABRB2TSHRCYP3A4NFKB1 | |
| SCHEMBL14395925 | 0.79 | CYP2D6 (0.54) | GABRA1GABRB2TSHRCYP3A4NFKB1 | |
| SCHEMBL30678523 | 0.79 | CYP2D6 (0.54) | GABRA1GABRB2TSHRCYP3A4NFKB1 | |
| SCHEMBL17448132 | 0.79 | CYP2D6 (0.54) | GABRA1GABRB2TSHRCYP3A4NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117321156-A | CMP composition for abrading dielectric materials | 恩特格里斯公司 | 2023-12-29 | — | — | CN | disclosed |