Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.52 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | FPR2 | P25090 | 2/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | CKS1B | P61024 | 1/20 | 0.41 |
| ▸ | SKP1 | P63208 | 1/20 | 0.41 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.41 |
| ▸ | FPR3 | P25089 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30066214 | 0.96 | GPR119 (0.52) | GPR119FAAHCNR1FPR2LRRK2 | |
| SCHEMBL24671505 | 0.96 | GPR119 (0.52) | GPR119FAAHCNR1FPR2LRRK2 | |
| SCHEMBL30179976 | 0.86 | GPR119 (0.54) | GPR119LRRK2CKS1BSKP1SKP2 | |
| SCHEMBL901264 | 0.86 | GPR119 (0.54) | GPR119LRRK2CKS1BSKP1SKP2 | |
| SCHEMBL29132200 | 0.86 | GPR119 (0.54) | GPR119FAAH | |
| SCHEMBL29132186 | 0.84 | GPR119 (0.48) | GPR119FAAHCNR1 | |
| SCHEMBL29132207 | 0.83 | GPR119 (0.52) | GPR119FAAH | |
| SCHEMBL7650536 | 0.83 | GPR119 (0.55) | GPR119FAAHCNR1CKS1BSKP1 | |
| SCHEMBL29132048 | 0.82 | GPR119 (0.57) | GPR119 | |
| SCHEMBL31584217 | 0.82 | GPR119 (0.50) | GPR119FAAHCNR1LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308557-A1 | INDAZOLE BASED COMPOUNDS AND ASSOCIATED METHODS OF USE | Arvinas Operations, Inc. (US) | 2024-01-24 | — | — | EP | disclosed |
| CN-117321046-A | Indazole-based compounds and related methods of use | 阿维纳斯企业公司 | 2023-12-29 | — | — | CN | disclosed |
| WO-2022198112-A1 | INDAZOLE BASED COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2022-09-22 | — | — | WO | disclosed |