Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2909845 | 1.00 | GSK3B (0.42) | GSK3BMAPTLMNAMAPK1ALDH1A1 | |
| SCHEMBL2910724 | 0.88 | GSK3B (0.42) | GSK3BMAPTLMNAMAPK1ALDH1A1 | |
| SCHEMBL2912944 | 0.88 | GSK3B (0.42) | GSK3BMAPTLMNAMAPK1ALDH1A1 | |
| SCHEMBL2912974 | 0.86 | GSK3B (0.47) | GSK3BMAPTLMNAMAPK1ALDH1A1 | |
| SCHEMBL2904288 | 0.85 | PPARD (0.41) | — | |
| SCHEMBL2904248 | 0.85 | PPARD (0.41) | — | |
| SCHEMBL2912712 | 0.85 | GSK3B (0.46) | GSK3B | |
| SCHEMBL2911861 | 0.85 | GSK3B (0.46) | GSK3B | |
| SCHEMBL2909835 | 0.85 | GSK3B (0.48) | GSK3BMAPTLMNAALDH1A1NPC1 | |
| SCHEMBL2912195 | 0.85 | GSK3B (0.48) | GSK3BMAPTLMNAALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537099-B1 | PYRROLE BASED INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2010-08-11 | — | — | EP | disclosed |