Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.40 |
| ▸ | CNR1 | P21554 | 2/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.38 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.38 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.38 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.38 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.38 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.38 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.38 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.38 |
| ▸ | GCGR | P47871 | 2/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.37 |
| ▸ | ACVR1B | P36896 | 3/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.36 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2904248 | 1.00 | PPARD (0.41) | PPARDHCRTR1CNR1F10P2RX7 | |
| SCHEMBL2910207 | 0.88 | ALOX5AP (0.40) | PPARDHCRTR1CNR1F10PRKAB2 | |
| SCHEMBL2911026 | 0.88 | ALOX5AP (0.40) | PPARDHCRTR1CNR1F10PRKAB2 | |
| SCHEMBL2912436 | 0.86 | F10 (0.41) | PPARDHCRTR1CNR1F10PRKAB2 | |
| SCHEMBL2911861 | 0.86 | GSK3B (0.46) | ACVR1BTGFBR1ACVRL1ACVR1 | |
| SCHEMBL2912712 | 0.86 | GSK3B (0.46) | ACVR1BTGFBR1ACVRL1ACVR1 | |
| SCHEMBL2913237 | 0.85 | GSK3B (0.42) | — | |
| SCHEMBL2909845 | 0.85 | GSK3B (0.42) | — | |
| SCHEMBL2909829 | 0.83 | HCRTR1 (0.41) | PPARDHCRTR1CNR1F10PRKAB2 | |
| SCHEMBL2909835 | 0.78 | GSK3B (0.48) | ACVR1BTGFBR1ACVRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537099-B1 | PYRROLE BASED INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2010-08-11 | — | — | EP | disclosed |