SCHEMBL29132544

SCHEMBL29132544

CC(C)(C)[Si](C)(C)OCCOCCCOCc1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 4/20 0.41
TDP1 Q9NUW8 1/20 0.41
TSHR P16473 1/20 0.41
NAAA Q02083 2/20 0.41
DUT P33316 2/20 0.41
HRH4 Q9H3N8 1/20 0.40
HRH3 Q9Y5N1 1/20 0.40
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
IDO1 P14902 1/20 0.35
KCNA3 P22001 1/20 0.35
KCNA5 P22460 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30378547 0.97 L3MBTL1 (0.41) L3MBTL1TDP1TSHRNAAADUT
SCHEMBL2560206 0.95 L3MBTL1 (0.47) L3MBTL1TDP1TSHRNAAADUT
SCHEMBL29960517 0.94 TSHR (0.44) L3MBTL1TDP1TSHRNAAADUT
SCHEMBL1743547 0.93 L3MBTL1 (0.47) L3MBTL1TDP1TSHRNAAADUT
SCHEMBL1742833 0.93 L3MBTL1 (0.47) L3MBTL1TDP1TSHRNAAADUT
SCHEMBL20305180 0.83 MEN1 (0.48) L3MBTL1TDP1DUTHRH4HRH3
SCHEMBL16829804 0.83 L3MBTL1 (0.38) L3MBTL1TDP1TSHRNAAADUT
SCHEMBL3726490 0.82 L3MBTL1 (0.43) L3MBTL1TDP1TSHRNAAAHRH4
SCHEMBL23768427 0.81 PLA2G10 (0.39) TSHRNAAADUTKMT2A
SCHEMBL16829989 0.81 CA1 (0.40) L3MBTL1TDP1TSHRHRH4HRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023193789-A1 WEE1 DEGRADING COMPOUNDS BEIJING NEOX BIOTECH LIMITED (CN) 2023-10-12 WO disclosed
CN-116829570-A WEE1 degrading compounds 北京星奇原生物科技有限公司 2023-09-29 CN disclosed