Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 12/20 | 0.52 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PDE1A | P54750 | 2/20 | 0.44 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.44 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.44 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.44 |
| ▸ | CMA1 | P23946 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | PKLR | P30613 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13964565 | 0.84 | NPBWR1 (0.55) | NPBWR1MCHR1ALDH1A1MAPTKDM4E | |
| SCHEMBL25045656 | 0.83 | NPBWR1 (0.57) | NPBWR1MCHR1ALDH1A1MAPTKDM4E | |
| SCHEMBL18096396 | 0.81 | NPBWR1 (0.52) | NPBWR1MCHR1ALDH1A1MAPTKDM4E | |
| SCHEMBL1491119 | 0.81 | TSHR (0.67) | NPBWR1MCHR1ALDH1A1MAPTKDM4E | |
| SCHEMBL25723425 | 0.79 | NPBWR1 (0.64) | NPBWR1MCHR1ALDH1A1SMN1; SMN2PDE1A | |
| SCHEMBL25833185 | 0.78 | NPBWR1 (0.49) | NPBWR1MCHR1ALDH1A1MAPTKDM4E | |
| SCHEMBL28496573 | 0.77 | NPBWR1 (0.51) | NPBWR1MCHR1ALDH1A1MAPTKDM4E | |
| SCHEMBL16252260 | 0.77 | UCHL1 (0.54) | NPBWR1MCHR1ALDH1A1MAPTKDM4E | |
| SCHEMBL4679664 | 0.77 | NPBWR1 (0.61) | NPBWR1MCHR1ALDH1A1SMN1; SMN2PDE1A | |
| SCHEMBL25756148 | 0.77 | NPBWR1 (0.61) | NPBWR1MCHR1ALDH1A1SMN1; SMN2PDE1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117285547-A | Macrocyclic compounds as modulators of CFTR, pharmaceutical compositions thereof, their use and methods of preparation | 弗特克斯药品有限公司 | 2023-12-26 | — | — | CN | disclosed |