Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.43 |
| ▸ | MEN1 | O00255 | 7/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL561004 | 0.83 | PDE2A (0.49) | PDE2AKMT2AMEN1HCRTR1MAPT | |
| SCHEMBL29467448 | 0.83 | PDE2A (0.49) | PDE2AKMT2AMEN1HCRTR1MAPT | |
| SCHEMBL23872469 | 0.81 | PDE2A (0.42) | PDE2AKMT2AMEN1HCRTR1KDM4E | |
| SCHEMBL19953345 | 0.79 | MAPT (0.49) | KMT2AMEN1MAPTKDM4EALDH1A1 | |
| SCHEMBL29786728 | 0.79 | MAPT (0.49) | KMT2AMEN1MAPTKDM4EALDH1A1 | |
| SCHEMBL19953294 | 0.78 | KMT2A (0.40) | PDE2AKMT2AMEN1HCRTR1MAPT | |
| SCHEMBL20674220 | 0.78 | PDE2A (0.40) | PDE2AKMT2AMEN1HCRTR1MAPT | |
| SCHEMBL30899643 | 0.78 | PDE2A (0.40) | PDE2AKMT2AMEN1ALDH1A1KCNH2 | |
| SCHEMBL24654997 | 0.78 | KMT2A (0.41) | PDE2AKMT2AMEN1HCRTR1MAPT | |
| SCHEMBL30935932 | 0.78 | PDE2A (0.40) | PDE2AKMT2AMEN1HCRTR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118076604-A | Pyrazolo [3,4-b ] pyridine compounds for the treatment of autoimmune diseases | 豪夫迈·罗氏有限公司 | 2024-05-24 | — | — | CN | disclosed |
| EP-4182032-A1 | HYDROISOQUINOLINE OR HYDRONAPHTHYRIDINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. Hoffmann-La Roche AG (CH) | 2023-05-24 | — | — | EP | disclosed |
| CN-115835910-A | Hydrogenated isoquinoline or naphthyridine compounds for the treatment of autoimmune diseases | 豪夫迈·罗氏有限公司 | 2023-03-21 | — | — | CN | disclosed |