Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABHD6 | Q9BV23 | 3/20 | 0.42 |
| ▸ | GHSR | Q92847 | 11/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20504327 | 0.90 | GHSR (0.44) | ABHD6GHSRNR1H2NR1H3 | |
| SCHEMBL20504328 | 0.90 | GHSR (0.44) | ABHD6GHSRNR1H2NR1H3 | |
| SCHEMBL29676621 | 0.83 | NR1H2 (0.43) | ABHD6GHSRNR1H2NR1H3ESR1 | |
| SCHEMBL12280043 | 0.83 | NR1H2 (0.43) | ABHD6GHSRNR1H2NR1H3ESR1 | |
| SCHEMBL19026010 | 0.80 | GHSR (0.44) | GHSRNR1H2NR1H3 | |
| SCHEMBL33532880 | 0.80 | UCHL1 (0.52) | ABHD6GHSRNR1H2NR1H3USP30 | |
| SCHEMBL19026148 | 0.80 | GHSR (0.44) | GHSRNR1H2NR1H3 | |
| SCHEMBL19025987 | 0.80 | GHSR (0.44) | GHSRNR1H2NR1H3 | |
| SCHEMBL27276905 | 0.79 | ESR1 (0.51) | GHSRNR1H2NR1H3ESR1ESR2 | |
| SCHEMBL2792433 | 0.78 | CYP2D6 (0.44) | ABHD6NR1H2NR1H3ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313967-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2024-02-07 | — | — | EP | disclosed |
| CN-117120429-A | KHK inhibitor | 吉利德科学公司 | 2023-11-24 | — | — | CN | disclosed |
| WO-2022212194-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2022-10-06 | — | — | WO | disclosed |