SCHEMBL29134638

SCHEMBL29134638

Cc1cn2cc(N)c(C)cc2n1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
APP P05067 1/20 0.40
UHRF1 Q96T88 1/20 0.38
TERT O14746 1/20 0.36
TLR9 Q9NR96 1/20 0.35
TLR8 Q9NR97 1/20 0.35
TLR7 Q9NYK1 1/20 0.35
SMN1; SMN2 Q16637 4/20 0.35
PIK3CG P48736 2/20 0.35
HDAC1 Q13547 1/20 0.35
CYP3A4 P08684 2/20 0.34
TSHR P16473 2/20 0.34
MAPK1 P28482 1/20 0.34
NOS3 P29474 1/20 0.34
NOS1 P29475 1/20 0.34
NOS2 P35228 1/20 0.34
ALDH1A1 P00352 4/20 0.33
KDM4E B2RXH2 3/20 0.33
NPC1 O15118 3/20 0.33
RAB9A P51151 3/20 0.33
GAA P10253 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL17765379 0.98 APP (0.39) APPUHRF1TERTTLR9TLR8
SCHEMBL12920735 0.81 TLR9 (0.37) TLR9TLR8TLR7SMN1; SMN2PIK3CG
SCHEMBL25420123 0.81 TLR9 (0.38) APPTLR9TLR8TLR7SMN1; SMN2
SCHEMBL24163152 0.80 HDAC1 (0.38) APPTLR9TLR8TLR7SMN1; SMN2
Hydrochloric Acid SCHEMBL31600165 0.79 TLR9 (0.38) APPTLR9TLR8TLR7SMN1; SMN2
SCHEMBL31601020 0.78 HPGD (0.41) PIK3CGHDAC1HPGDHSD17B10
SCHEMBL24033637 0.78 ALDH1A1 (0.39) TLR9TLR7SMN1; SMN2CYP3A4TSHR
Hydrochloric Acid SCHEMBL31600043 0.77 ALDH1A1 (0.38) TLR9TLR7SMN1; SMN2CYP3A4TSHR
SCHEMBL29134351 0.77 NOS3 (0.33) APPTLR9TLR8TLR7SMN1; SMN2
SCHEMBL8373761 0.75 RXFP1 (0.51) APPSMN1; SMN2CYP3A4TSHRMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025111547-A1 2,3-DIHYDROPYROLLOPYRIDINE CARBOXAMIDE COMPOUNDS AND METHODS OF USE THEREOF RGENTA THERAPEUTICS, INC. (US) 2025-05-30 WO disclosed
CN-116997548-A HTT modulators for the treatment of huntington's disease CHDI基金会股份有限公司 2023-11-03 CN disclosed
EP-4149937-A1 HTT MODULATORS FOR TREATING HUNTINGTON'S DISEASE CHDI Foundation, Inc. (US) 2023-03-22 EP disclosed