SCHEMBL29134657

SCHEMBL29134657

O=NOC(=O)c1ccnc(-c2ccc(F)cc2)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.46
POLB P06746 1/20 0.46
KDM4C Q9H3R0 5/20 0.43
KDM5A P29375 3/20 0.43
KDM5B Q9UGL1 3/20 0.43
KDM4A O75164 2/20 0.43
KDM4E B2RXH2 1/20 0.42
KDM6B O15054 1/20 0.42
KDM5C P41229 1/20 0.42
KDM2A Q9Y2K7 1/20 0.42
KDM3A Q9Y4C1 1/20 0.42
KMO O15229 1/20 0.40
SCN10A Q9Y5Y9 1/20 0.40
NPC1 O15118 4/20 0.40
RAB9A P51151 3/20 0.40
MEN1 O00255 2/20 0.40
ABL1 P00519 1/20 0.40
BCR P11274 1/20 0.40
ATM Q13315 1/20 0.40
RXFP1 Q9HBX9 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29134643 0.86 KDM1A (0.47) KMT2APOLBKDM4CKDM4EKDM6B
SCHEMBL28651256 0.85 KAT6A (0.48) KMT2APOLBKDM4CKDM5BKDM4A
SCHEMBL29134646 0.83 KDM1A (0.51) KMT2APOLBKDM4CKDM5AKDM5B
SCHEMBL31211658 0.82 KDM4E (0.63) KMT2AKDM4CKDM5AKDM5BKDM4A
SCHEMBL1516921 0.82 KDM4E (0.63) KMT2AKDM4CKDM5AKDM5BKDM4A
Hydrochloric Acid SCHEMBL581959 0.81 KDM4E (0.61) KMT2AKDM4CKDM5AKDM5BKDM4A
SCHEMBL28856057 0.80 MAP4K4 (0.54) KMT2AKDM4CKDM5AKDM5BKDM4A
Nitrous Acid SCHEMBL29134658 0.79 KDM4C (0.57) KDM4CKDM5AKDM5BKDM4AKDM4E
SCHEMBL4770697 0.79 JMJD6 (0.59) KMT2AKDM4ENPC1RAB9AMEN1
SCHEMBL29072870 0.79 KMT2A (0.43) KMT2APOLBKDM4CKDM4EKDM6B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117343002-A Synthesis method of beta-cyanoalkyl pyridine compound 西南医科大学 2024-01-05 CN disclosed