SCHEMBL29134643

SCHEMBL29134643

Cc1ccc(-c2cc(C(=O)ON=O)ccn2)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM1A O60341 2/20 0.47
HDAC1 Q13547 2/20 0.47
ALDH1A1 P00352 3/20 0.46
KMT2A Q03164 2/20 0.46
KDM4C Q9H3R0 2/20 0.46
KDM4E B2RXH2 1/20 0.46
KDM6B O15054 1/20 0.46
KDM5C P41229 1/20 0.46
KDM2A Q9Y2K7 1/20 0.46
KDM3A Q9Y4C1 1/20 0.46
SCN10A Q9Y5Y9 1/20 0.46
HDAC6 Q9UBN7 1/20 0.45
KDM2B Q8NHM5 1/20 0.44
NPC1 O15118 3/20 0.42
PKM P14618 2/20 0.42
RAB9A P51151 2/20 0.42
JMJD6 Q6NYC1 4/20 0.41
ABL1 P00519 2/20 0.41
BCR P11274 2/20 0.41
KMO O15229 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29134646 0.86 KDM1A (0.51) KDM1AHDAC1ALDH1A1KMT2AKDM4C
SCHEMBL29134657 0.86 KMT2A (0.46) KMT2AKDM4CKDM4EKDM6BKDM5C
SCHEMBL28651256 0.85 KAT6A (0.48) ALDH1A1KMT2AKDM4CKDM4EKDM6B
SCHEMBL29141517 0.84 KDM4E (0.65) KDM1AHDAC1KDM4CKDM4EKDM6B
SCHEMBL4763737 0.81 JMJD6 (0.61) KDM1AHDAC1KDM4CKDM4EKDM6B
SCHEMBL29932995 0.80 MAP4K4 (0.54) KDM1AHDAC1KMT2AKDM4CKDM5C
Nitrous Acid SCHEMBL29134645 0.79 KDM4C (0.59) KDM1AHDAC1ALDH1A1KDM4CKDM4E
SCHEMBL30775014 0.79 KDM4C (0.64) KDM1AHDAC1ALDH1A1KDM4CKDM4E
SCHEMBL29163838 0.78 SMYD2 (0.47) ALDH1A1KMT2AKDM4CKDM4EKDM6B
SCHEMBL27997808 0.74 KDM4E (0.69) KDM1AHDAC1ALDH1A1KDM4CKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117343002-A Synthesis method of beta-cyanoalkyl pyridine compound 西南医科大学 2024-01-05 CN disclosed