Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | CASP6 | P55212 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.32 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28319611 | 0.79 | L3MBTL1 (0.33) | TDP1L3MBTL1MAPTALDH1A1CASP7 | |
| SCHEMBL10420191 | 0.74 | DYRK1A (0.42) | TDP1L3MBTL1MAPTALDH1A1HTT | |
| SCHEMBL6684736 | 0.72 | ADORA2A (0.42) | TDP1MAPTALDH1A1CASP7CASP6 | |
| SCHEMBL1663754 | 0.71 | PDE4D (0.59) | L3MBTL1PDE4DKDM4EDAOHCAR2 | |
| SCHEMBL9353447 | 0.71 | TDP1 (0.39) | TDP1L3MBTL1MAPTALDH1A1CASP7 | |
| SCHEMBL2542592 | 0.71 | MEN1 (0.39) | TDP1L3MBTL1MAPTALDH1A1HTT | |
| SCHEMBL11340041 | 0.70 | MAPT (0.42) | TDP1L3MBTL1MAPTALDH1A1CASP7 | |
| Methyl Alcohol SCHEMBL28814352 | 0.70 | PARP1 (0.41) | TDP1L3MBTL1MAPTALDH1A1RAB9A | |
| SCHEMBL27860693 | 0.68 | PARP1 (0.43) | L3MBTL1MAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL22558031 | 0.68 | PDE4D (0.41) | L3MBTL1PDE4DALDH1A1HTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |
| EP-1051399-A1 | PHENYLALANINE DERIVATIVES USEFUL AS PHARMACEUTICAL AGENTS | CELLTECH THERAPEUTICS LIMITED (GB) | 2000-11-15 | — | — | EP | disclosed |
| WO-1999037618-A1 | PHENYLALANINE DERIVATIVES USEFUL AS PHARMACEUTICAL AGENTS | CELLTECH THERAPEUTICS LIMITED (GB) | 1999-07-29 | — | — | WO | disclosed |