Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.41 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.41 |
| ▸ | PTGER3 | P43115 | 3/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29779055 | 1.00 | MKNK1 (0.43) | MKNK1MKNK2LMNAMAPTALOX15 | |
| SCHEMBL24617388 | 0.88 | LMNA (0.34) | MKNK1MKNK2LMNAMAPTTSHR | |
| SCHEMBL29778646 | 0.86 | MKNK1 (0.45) | MKNK1MKNK2LMNAMAPTMEN1 | |
| SCHEMBL24617390 | 0.86 | MKNK1 (0.45) | MKNK1MKNK2LMNAMAPTMEN1 | |
| SCHEMBL29778702 | 0.84 | MKNK1 (0.46) | MKNK1MKNK2LMNAMAPTMEN1 | |
| SCHEMBL24617705 | 0.84 | MKNK1 (0.46) | MKNK1MKNK2LMNAMAPTMEN1 | |
| SCHEMBL24616899 | 0.84 | ROCK2 (0.41) | LMNAMAPTMEN1TSHRKMT2A | |
| SCHEMBL24617391 | 0.82 | MKNK1 (0.48) | MKNK1MKNK2LMNAMAPTMEN1 | |
| SCHEMBL29778396 | 0.82 | MKNK1 (0.48) | MKNK1MKNK2LMNAMAPTMEN1 | |
| SCHEMBL24617332 | 0.80 | MKNK1 (0.47) | MKNK1MKNK2LMNAMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117136186-A | Selective inhibitors of ROCK1 and ROCK2 protein kinases and uses thereof | 盖诺斯克公司 | 2023-11-28 | — | — | CN | claimed |
| CN-117136186-A | Selective inhibitors of ROCK1 and ROCK2 protein kinases and uses thereof | 盖诺斯克公司 | 2023-11-28 | — | — | CN | disclosed |