Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 1/20 | 0.35 |
| ▸ | GRK2 | P25098 | 2/20 | 0.34 |
| ▸ | METAP2 | P50579 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.30 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.30 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29135974 | 1.00 | GCK (0.35) | GCKGRK2METAP2EGFRTSHR | |
| SCHEMBL29778561 | 1.00 | GCK (0.35) | GCKGRK2METAP2EGFRTSHR | |
| SCHEMBL29778559 | 0.90 | GRK2 (0.41) | GCKGRK2METAP2EGFRTSHR | |
| SCHEMBL29135954 | 0.90 | GRK2 (0.41) | GCKGRK2METAP2EGFRTSHR | |
| SCHEMBL29135956 | 0.90 | GRK2 (0.41) | GCKGRK2METAP2EGFRTSHR | |
| SCHEMBL24617373 | 0.88 | METAP2 (0.36) | GCKGRK2METAP2EGFRTSHR | |
| SCHEMBL24617321 | 0.88 | METAP2 (0.36) | GCKGRK2METAP2EGFRTSHR | |
| SCHEMBL29778479 | 0.83 | LIPC (0.34) | GCKGRK2METAP2EGFRTSHR | |
| SCHEMBL29778571 | 0.82 | GRK2 (0.41) | GRK2CDK9ROCK2ROCK1 | |
| SCHEMBL29135985 | 0.82 | GRK2 (0.41) | GRK2CDK9ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117136186-A | Selective inhibitors of ROCK1 and ROCK2 protein kinases and uses thereof | 盖诺斯克公司 | 2023-11-28 | — | — | CN | claimed |
| CN-117136186-A | Selective inhibitors of ROCK1 and ROCK2 protein kinases and uses thereof | 盖诺斯克公司 | 2023-11-28 | — | — | CN | disclosed |