Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 4/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.49 |
| ▸ | TDO2 | P48775 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | WNT1 | P04628 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | GRK2 | P25098 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.37 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29778579 | 1.00 | ROCK2 (0.49) | ROCK2ROCK1TDO2KDM4ESMN1; SMN2 | |
| SCHEMBL24617619 | 0.89 | ROCK2 (0.41) | ROCK2ROCK1TDO2KDM4ESMN1; SMN2 | |
| SCHEMBL29778415 | 0.89 | ROCK2 (0.51) | ROCK2ROCK1TDO2KDM4ESMN1; SMN2 | |
| SCHEMBL24616945 | 0.89 | ROCK2 (0.51) | ROCK2ROCK1TDO2KDM4ESMN1; SMN2 | |
| SCHEMBL24617616 | 0.89 | MAPK1 (0.40) | ROCK2ROCK1TDO2KDM4ESMN1; SMN2 | |
| SCHEMBL24616843 | 0.88 | KCNH2 (0.45) | ROCK2ROCK1WNT1GSK3BDYRK1A | |
| SCHEMBL24617437 | 0.88 | TDO2 (0.43) | ROCK2ROCK1TDO2KDM4ESMN1; SMN2 | |
| SCHEMBL24617348 | 0.88 | KDM4E (0.42) | ROCK2ROCK1TDO2KDM4ESMN1; SMN2 | |
| SCHEMBL24617539 | 0.87 | ROCK2 (0.51) | ROCK2ROCK1TDO2KDM4ESMN1; SMN2 | |
| SCHEMBL24617030 | 0.87 | ROCK2 (0.51) | ROCK2ROCK1TDO2KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117136186-A | Selective inhibitors of ROCK1 and ROCK2 protein kinases and uses thereof | 盖诺斯克公司 | 2023-11-28 | — | — | CN | claimed |
| CN-117136186-A | Selective inhibitors of ROCK1 and ROCK2 protein kinases and uses thereof | 盖诺斯克公司 | 2023-11-28 | — | — | CN | disclosed |