Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 2/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30089057 | 1.00 | CHEK2 (0.51) | CHEK2PDE4BGPR119USP30HRH3 | |
| SCHEMBL7404268 | 0.90 | CHEK2 (0.49) | CHEK2PDE4BGPR119USP30HRH3 | |
| SCHEMBL7475681 | 0.89 | PDE4B (0.52) | CHEK2PDE4BGPR119USP30ALDH1A1 | |
| SCHEMBL7399691 | 0.89 | GPR119 (0.53) | CHEK2PDE4BGPR119HRH3ALDH1A1 | |
| SCHEMBL27177265 | 0.86 | HRH3 (0.46) | CHEK2HRH3ALDH1A1MEN1KMT2A | |
| SCHEMBL27177260 | 0.86 | HRH3 (0.46) | CHEK2HRH3ALDH1A1MEN1KMT2A | |
| SCHEMBL27143206 | 0.85 | GPR119 (0.49) | CHEK2PDE4BGPR119USP30HRH3 | |
| SCHEMBL27150382 | 0.85 | GPR119 (0.49) | CHEK2PDE4BGPR119USP30HRH3 | |
| SCHEMBL31385735 | 0.83 | PDE4B (0.54) | PDE4BUSP30MEN1KMT2A | |
| SCHEMBL7480141 | 0.83 | GPR119 (0.48) | CHEK2PDE4BGPR119USP30HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117321042-A | Oxodihydro indole compounds for the treatment of inflammatory diseases or cancers | 豪夫迈·罗氏有限公司 | 2023-12-29 | — | — | CN | disclosed |