Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2309241 | 0.98 | ALDH1A1 (0.50) | ALDH1A1MAPTGLAKMT2AHSD17B10 | |
| SCHEMBL23915341 | 0.79 | MAOB (0.40) | ALDH1A1MAPTKMT2AKDM4EHTT | |
| SCHEMBL86913 | 0.79 | PTPRC (0.38) | ALDH1A1KMT2AKDM4ELMNA | |
| SCHEMBL23972246 | 0.77 | ALDH1A1 (0.44) | ALDH1A1MAPTGLAKMT2AHSD17B10 | |
| SCHEMBL21268021 | 0.76 | ALDH1A1 (0.48) | ALDH1A1MAPTGLAKMT2AHSD17B10 | |
| SCHEMBL23909130 | 0.73 | C1R (0.34) | ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL87116 | 0.73 | ALDH1A1 (0.35) | ALDH1A1MAPTKMT2AKDM4ELMNA | |
| SCHEMBL6200500 | 0.73 | KDM4E (0.46) | ALDH1A1KDM4ELMNA | |
| SCHEMBL87177 | 0.70 | C1R (0.38) | ALDH1A1MAPTKMT2AHSD17B10KDM4E | |
| SCHEMBL29791776 | 0.69 | ALDH1A1 (0.59) | ALDH1A1KMT2AHSD17B10KDM4ECA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117321044-A | Poly (ADP-ribose) polymerase inhibitors | 理森制药股份公司 | 2023-12-29 | — | — | CN | disclosed |