Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METTL3 | Q86U44 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.34 |
| ▸ | KLKB1 | P03952 | 8/20 | 0.34 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.33 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29136812 | 0.98 | METTL3 (0.37) | METTL3LRRK2KLKB1MAP3K5ABL1 | |
| SCHEMBL21845499 | 0.80 | METTL3 (0.36) | METTL3LRRK2KLKB1DGAT1MAP4K1 | |
| SCHEMBL23452838 | 0.78 | METTL3 (0.35) | METTL3LRRK2KLKB1DGAT1 | |
| SCHEMBL21359015 | 0.77 | METTL3 (0.35) | METTL3KLKB1DGAT1KDM4E | |
| SCHEMBL27030315 | 0.77 | KDM4E (0.60) | METTL3KLKB1KDM4ETP53 | |
| SCHEMBL28790408 | 0.77 | KLKB1 (0.50) | METTL3KLKB1 | |
| Hydrochloric Acid SCHEMBL27030313 | 0.76 | KDM4E (0.58) | METTL3KLKB1KDM4ETP53 | |
| SCHEMBL24834491 | 0.75 | NPC1 (0.52) | MAP3K5KDM4ETP53 | |
| SCHEMBL24729704 | 0.75 | METTL3 (0.44) | METTL3KLKB1KDM4ETP53 | |
| SCHEMBL29137005 | 0.75 | METTL3 (0.37) | METTL3KLKB1DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117396473-A | Imidazopyridinyl inhibitors of plasma kallikrein | 武田药品工业株式会社 | 2024-01-12 | — | — | CN | disclosed |
| CN-117396474-A | Plasma kallikrein inhibitors | 武田药品工业株式会社 | 2024-01-12 | — | — | CN | disclosed |
| CN-117355521-A | Heteroaryl inhibitors of plasma kallikrein | 武田药品工业株式会社 | 2024-01-05 | — | — | CN | disclosed |
| CN-117355523-A | Polycyclic inhibitors of plasma kallikrein | 武田药品工业株式会社 | 2024-01-05 | — | — | CN | disclosed |