Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24738087 | 0.87 | PSEN1 (0.41) | LMNAPPARGPPARDKMT2AMEN1 | |
| SCHEMBL2945158 | 0.84 | CA2 (0.45) | KMT2AMEN1HTR6PSEN1PSEN2 | |
| SCHEMBL2945154 | 0.84 | CA2 (0.45) | KMT2AMEN1HTR6PSEN1PSEN2 | |
| SCHEMBL2135065 | 0.72 | CA2 (0.43) | KMT2AMEN1PSEN1PSEN2APH1B | |
| SCHEMBL12787980 | 0.70 | CYP1A2 (0.52) | LMNAPPARGCYP3A4CYP2D6ALDH1A1 | |
| SCHEMBL30302203 | 0.68 | NR1H2 (0.49) | LMNAKMT2AMEN1MAPTPTGDR2 | |
| SCHEMBL1051004 | 0.68 | CYP1A2 (0.57) | LMNAPPARGCYP3A4CYP2D6AKR1B1 | |
| SCHEMBL2135077 | 0.68 | SLC9A1 (0.44) | HTR6PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1051005 | 0.68 | CYP1A2 (0.57) | LMNAPPARGCYP3A4CYP2D6AKR1B1 | |
| SCHEMBL2135071 | 0.68 | SLC9A1 (0.44) | HTR6PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117355521-A | Heteroaryl inhibitors of plasma kallikrein | 武田药品工业株式会社 | 2024-01-05 | — | — | CN | disclosed |