Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Dl-Phenylalanine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.51 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.51 |
| ▸ | ALPI | P09923 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | XIAP | P98170 | 1/20 | 0.51 |
| ▸ | ANPEP | P15144 | 2/20 | 0.48 |
| ▸ | RNPEP | Q9H4A4 | 2/20 | 0.48 |
| ▸ | DNPEP | Q9ULA0 | 2/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | GSR | P00390 | 1/20 | 0.47 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.46 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.46 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.45 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenylalanine SCHEMBL7050181 | 1.00 | SLC7A5 (0.51) | SLC7A5ALPIPKMPTGS1XIAP | |
| Dl-Phenylalanine SCHEMBL28416148 | 0.98 | SLC7A5 (0.49) | SLC7A5ALPIPKMPTGS1XIAP | |
| Phenylalanine SCHEMBL723829 | 0.94 | SLC7A5 (0.58) | SLC7A5ALPIPKMPTGS1XIAP | |
| Dl-Phenylalanine SCHEMBL3691104 | 0.94 | SLC7A5 (0.58) | SLC7A5ALPIPKMPTGS1XIAP | |
| Dl-Phenylalanine SCHEMBL23120449 | 0.94 | THRB (0.46) | SLC7A5ALPIPKMPTGS1XIAP | |
| Dl-Phenylalanine SCHEMBL27473663 | 0.93 | ALPI (0.44) | SLC7A5ALPIPKMPTGS1XIAP | |
| Phenylalanine SCHEMBL1065019 | 0.89 | SLC7A5 (0.65) | SLC7A5ALPIPKMPTGS1XIAP | |
| Phenylalanine SCHEMBL1000408 | 0.89 | SLC7A5 (0.65) | SLC7A5ALPIPKMPTGS1XIAP | |
| Phenylalanine SCHEMBL9714683 | 0.88 | SLC7A5 (0.51) | SLC7A5ALPIPKMPTGS1XIAP | |
| Phenylalanine SCHEMBL1499939 | 0.87 | SLC7A5 (0.58) | SLC7A5ALPIPKMPTGS1XIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116870136-A | Polypeptide nanomaterial for combining PD-L1 and preparation method and application thereof | 南方科技大学 | 2023-10-13 | — | — | CN | disclosed |