Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 3/20 | 0.39 |
| ▸ | MAOB | P27338 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | KIF11 | P52732 | 2/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16370735 | 0.85 | MAOB (0.46) | MAOB | |
| SCHEMBL2907966 | 0.78 | MAPT (0.53) | MAPTLMNATHRBPKMMAOA | |
| SCHEMBL2056398 | 0.78 | KIF11 (0.56) | MAPTLMNATHRBPKMMAOA | |
| SCHEMBL10264823 | 0.75 | MAPT (0.50) | MAPTLMNATHRBPKMMAOA | |
| SCHEMBL21024967 | 0.74 | MAPT (0.49) | MAPTLMNATHRBPKMMAOA | |
| SCHEMBL16233050 | 0.74 | KIF11 (0.48) | MAPTLMNAPKMMAOAMAOB | |
| SCHEMBL22255816 | 0.73 | CRBN (0.46) | MAPTTHRBPKMMAOAMAOB | |
| SCHEMBL5766779 | 0.72 | MAPT (0.50) | MAPTLMNATHRBPKMMAOA | |
| SCHEMBL19410064 | 0.72 | MAPT (0.50) | MAPTPKMTP53KIF11 | |
| SCHEMBL10333350 | 0.72 | MAPT (0.46) | MAPTLMNATHRBPKMMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |