Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | KIF11 | P52732 | 3/20 | 0.41 |
| ▸ | PKM | P14618 | 3/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.39 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2056398 | 0.84 | KIF11 (0.56) | MAPTLMNAKIF11PKMTHRB | |
| SCHEMBL10264823 | 0.81 | MAPT (0.50) | MAPTLMNAKIF11PKMTHRB | |
| SCHEMBL2907966 | 0.78 | MAPT (0.53) | MAPTLMNAKIF11PKMTHRB | |
| SCHEMBL21024967 | 0.77 | MAPT (0.49) | MAPTLMNAKIF11PKMTHRB | |
| SCHEMBL26003771 | 0.76 | MAOA (0.50) | MAPTKIF11MAOAMAOBSMN1; SMN2 | |
| SCHEMBL5766779 | 0.75 | MAPT (0.50) | MAPTLMNAKIF11PKMTHRB | |
| SCHEMBL2056365 | 0.74 | KIF11 (0.66) | MAPTLMNAKIF11PKMMAOA | |
| SCHEMBL10274553 | 0.72 | MAPT (0.53) | MAPTLMNAKIF11PKMIDO1 | |
| SCHEMBL8206503 | 0.72 | MAPT (0.58) | MAPTLMNAKIF11PKMIDO1 | |
| SCHEMBL2913806 | 0.72 | MAPT (0.43) | MAPTLMNAKIF11PKMTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4916128-A | Thiadiazinones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1990-04-10 | — | — | US | disclosed |