Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.61 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.54 |
| ▸ | KDM4C | Q9H3R0 | 17/20 | 0.50 |
| ▸ | KDM5A | P29375 | 14/20 | 0.50 |
| ▸ | KDM5B | Q9UGL1 | 13/20 | 0.50 |
| ▸ | KDM4A | O75164 | 4/20 | 0.49 |
| ▸ | KDM2B | Q8NHM5 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | KDM6B | O15054 | 1/20 | 0.47 |
| ▸ | TET3 | O43151 | 1/20 | 0.47 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KDM5C | P41229 | 1/20 | 0.47 |
| ▸ | ASPH | Q12797 | 1/20 | 0.47 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.47 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.47 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.47 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.47 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30775157 | 1.00 | PIK3CA (0.61) | PIK3CAPROKR1KDM4CKDM5AKDM5B | |
| Nitrous Acid SCHEMBL29139860 | 0.94 | PIK3CA (0.56) | PIK3CAPROKR1KDM4CKDM5AKDM5B | |
| SCHEMBL3743262 | 0.84 | PIK3CA (0.67) | PIK3CAPROKR1KDM4CKDM5AKDM5B | |
| SCHEMBL19202594 | 0.82 | PROKR1 (0.53) | PIK3CAPROKR1KDM4CKDM5AKDM5B | |
| SCHEMBL30378524 | 0.82 | PROKR1 (0.53) | PIK3CAPROKR1KDM4CKDM5AKDM5B | |
| SCHEMBL31143236 | 0.80 | PIK3CA (0.74) | PIK3CAPROKR1KDM4CKDM5AKDM5B | |
| SCHEMBL1516867 | 0.80 | PIK3CA (0.74) | PIK3CAPROKR1KDM4CKDM5AKDM5B | |
| SCHEMBL29139858 | 0.80 | PROKR1 (0.48) | PIK3CAPROKR1KDM4CKDM5AKDM5B | |
| Hydrochloric Acid SCHEMBL1252523 | 0.79 | PIK3CA (0.72) | PIK3CAPROKR1KDM4CKDM5AKDM5B | |
| SCHEMBL1255519 | 0.79 | PIK3CA (0.72) | PIK3CAPROKR1KDM4CKDM5AKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117924266-A | Compounds that modulate FXR (NR 1H 4) | 吉利德科学公司 | 2024-04-26 | — | — | CN | disclosed |
| CN-117924267-A | Compounds that modulate FXR (NR 1H 4) | 吉利德科学公司 | 2024-04-26 | — | — | CN | disclosed |
| CN-109476636-B | Compounds that modulate FXR (NR 1H 4) | 吉利德科学公司 | 2024-01-09 | — | — | CN | disclosed |