Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.67 |
| ▸ | KDM4C | Q9H3R0 | 10/20 | 0.50 |
| ▸ | KDM4A | O75164 | 4/20 | 0.50 |
| ▸ | KDM5A | P29375 | 8/20 | 0.48 |
| ▸ | KDM5B | Q9UGL1 | 6/20 | 0.48 |
| ▸ | KDM2B | Q8NHM5 | 3/20 | 0.47 |
| ▸ | PROKR1 | Q8TCW9 | 4/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.45 |
| ▸ | DPP4 | P27487 | 2/20 | 0.45 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.45 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | KDM6B | O15054 | 1/20 | 0.45 |
| ▸ | TET3 | O43151 | 1/20 | 0.45 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KDM5C | P41229 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3738805 | 0.87 | PIK3CA (0.65) | PIK3CAKDM4CKDM4AKDM5AKDM5B | |
| SCHEMBL16966428 | 0.87 | PIK3CA (0.65) | PIK3CAKDM4CKDM4AKDM5AKDM5B | |
| SCHEMBL30775157 | 0.84 | PIK3CA (0.61) | PIK3CAKDM4CKDM4AKDM5AKDM5B | |
| SCHEMBL29139855 | 0.84 | PIK3CA (0.61) | PIK3CAKDM4CKDM4AKDM5AKDM5B | |
| SCHEMBL1494841 | 0.84 | PIK3CA (0.62) | PIK3CAKDM4CKDM4AKDM5AKDM5B | |
| SCHEMBL1516867 | 0.84 | PIK3CA (0.74) | PIK3CAKDM4CKDM4AKDM5AKDM5B | |
| SCHEMBL31143236 | 0.84 | PIK3CA (0.74) | PIK3CAKDM4CKDM4AKDM5AKDM5B | |
| SCHEMBL12552657 | 0.83 | PIK3CA (0.60) | PIK3CAKDM4CKDM4AKDM5AKDM5B | |
| SCHEMBL20950150 | 0.83 | PIK3CA (0.60) | PIK3CAKDM4CKDM4AKDM5AKDM5B | |
| Hydrochloric Acid SCHEMBL1252523 | 0.83 | PIK3CA (0.72) | PIK3CAKDM4CKDM4AKDM5AKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100311754-A1 | 1,4-Disubstituted Naphthalenes as Inhibitors of P38 Map Kinase | ARQULE, INC. (US) | 2010-12-09 | — | — | US | disclosed |
| US-7829560-B2 | 1,4-disubstituted naphthalenes as inhibitors of P38 MAP kinase | ARQULE, INC. (US) | 2010-11-09 | — | — | US | disclosed |
| US-20080032967-A1 | 1,4-Disubstituted Naphthalenes as Inhibitors of P38 Map Kinase | ARQULE, INC. | 2008-02-07 | — | — | US | disclosed |
| EP-1615919-B1 | 7-([1,4]DIOXAN-2-YL)-BENZOTHIAZOLE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2007-08-22 | — | — | EP | disclosed |
| WO-2006010082-A1 | 1,4-DISUBSTITUTED NAPHTALENES AS INHIBITORS OF P38 MAP KINASE | ARQULE, INC. (US) | 2006-01-26 | — | — | WO | disclosed |
| US-6872833-B2 | Adenosine receptor ligands | HOFFMANN-LA ROCHE INC. (US) | 2005-03-29 | — | — | US | disclosed |
| US-20040204584-A1 | ADENOSINE RECEPTOR LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100311754-A1 | 1,4-Disubstituted Naphthalenes as Inhibitors of P38 Map Kinase | MAPK1, MAPK7, MAP3K1 | PIK3CA 3537/4885KDM4C 4011/4885KDM4A 4206/4885 |
| US-20040204584-A1 | ADENOSINE RECEPTOR LIGANDS | ADORA1, ADORA2A, ADORA3 | PIK3CA 1855/4885KDM4C 4701/4885KDM4A 4494/4885 |
| US-20080032967-A1 | 1,4-Disubstituted Naphthalenes as Inhibitors of P38 Map Kinase | MAPK1, MAPK8, MAPK4 | PIK3CA 2806/4885KDM4C 4381/4885KDM4A 4198/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.