Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 15/20 | 0.61 |
| ▸ | INSR | P06213 | 15/20 | 0.61 |
| ▸ | EGFR | P00533 | 2/20 | 0.57 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.46 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.46 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.46 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2913840 | 0.94 | MET (0.61) | METINSREGFRALKIGF1R | |
| SCHEMBL884795 | 0.91 | MET (0.71) | METINSREGFRALKIGF1R | |
| SCHEMBL884821 | 0.90 | INSR (0.71) | METINSREGFRALKIGF1R | |
| SCHEMBL886493 | 0.90 | MET (0.71) | METINSREGFRALKIGF1R | |
| SCHEMBL885058 | 0.89 | MET (0.69) | METINSREGFRALKIGF1R | |
| SCHEMBL2060845 | 0.86 | MET (0.74) | METINSREGFRALKIGF1R | |
| SCHEMBL885013 | 0.85 | MET (0.57) | METINSREGFRALKBRD4 | |
| SCHEMBL2062313 | 0.85 | MET (0.71) | METINSREGFRALKIGF1R | |
| SCHEMBL16966113 | 0.84 | MET (0.57) | METINSREGFRALKIGF1R | |
| SCHEMBL16966122 | 0.84 | MET (0.57) | METINSREGFRALKIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | claimed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | claimed |
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |