Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | NAMPT | P43490 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | MAOA | P21397 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20804370 | 0.89 | HPGD (0.67) | HPGDALDH1A1LMNAHTTPOLB | |
| SCHEMBL14797487 | 0.87 | HPGD (0.57) | HPGDALDH1A1LMNAHTTPOLB | |
| SCHEMBL31396790 | 0.87 | HPGD (0.59) | HPGDALDH1A1LMNAHTTNPC1 | |
| SCHEMBL1568699 | 0.87 | NAMPT (0.69) | HPGDLMNAHTTNPC1NAMPT | |
| SCHEMBL13947127 | 0.87 | HPGD (0.64) | HPGDALDH1A1LMNAHTTPOLB | |
| SCHEMBL3460904 | 0.83 | EPHX2 (0.57) | HPGDALDH1A1POLBNPC1 | |
| SCHEMBL3559924 | 0.83 | RIPK1 (0.58) | HPGDALDH1A1LMNAPOLBMAPT | |
| SCHEMBL3459833 | 0.82 | GAA (0.55) | HPGDALDH1A1LMNA | |
| SCHEMBL678599 | 0.82 | CA2 (0.71) | HPGDLMNA | |
| SCHEMBL1767796 | 0.82 | HPGD (0.51) | HPGDLMNAPOLBNPC1NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1586552-B1 | PROCESS FOR PRODUCING BENZYLAMINE DERIVATIVE | IHARA CHEMICAL IND CO (JP) | 2010-08-25 | — | — | EP | disclosed |
| US-7704995-B2 | Protein kinase modulators and methods of use | EXELIXIS, INC. (US) | 2010-04-27 | — | — | US | disclosed |
| CN-100503551-C | Process for producing benzylamine derivative | IHARA CHEMICAL IND CO (JP) | 2009-06-24 | — | — | CN | disclosed |
| US-7326813-B2 | Process for producing benzylamine derivative | IHARA CHEMICAL INDUSTRY (JP) | 2008-02-05 | — | — | US | disclosed |
| US-7241759-B2 | Benzo[1,2,5]thiadiazole compounds | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-07-10 | — | — | US | disclosed |
| US-20060211709-A1 | Protein kinase modulators and methods of use | EXELIXIS, INC. | 2006-09-21 | — | — | US | disclosed |
| US-20060155141-A1 | Process for producing benzylamine derivative | ITO AKINORI | 2006-07-13 | — | — | US | disclosed |
| CN-1802343-A | Process for producing benzylamine derivative | IHARA CHEMICAL IND CO (JP) | 2006-07-12 | — | — | CN | disclosed |
| EP-1586552-A1 | PROCESS FOR PRODUCING BENZYLAMINE DERIVATIVE | IHARA CHEMICAL INDUSTRY Co., Ltd. (JP) | 2005-10-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060155141-A1 | Process for producing benzylamine derivative | BRD7, BRD1, BRD2 | HPGD 2426/4885ALDH1A1 2660/4885LMNA 2089/4885 |
| US-20060211709-A1 | Protein kinase modulators and methods of use | GRK2, MAP4K2, MAPKAPK2 | HPGD 1272/4885ALDH1A1 3298/4885LMNA 3773/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.