Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dopamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.62 |
| ▸ | MAPT | P10636 | 4/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.62 |
| ▸ | RECQL | P46063 | 3/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.62 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.62 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.62 |
| ▸ | DRD2 | P14416 | 2/20 | 0.62 |
| ▸ | DRD1 | P21728 | 2/20 | 0.62 |
| ▸ | DRD4 | P21917 | 2/20 | 0.62 |
| ▸ | DRD5 | P21918 | 2/20 | 0.62 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.62 |
| ▸ | DRD3 | P35462 | 2/20 | 0.62 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.62 |
| ▸ | APEX1 | P27695 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dopamine SCHEMBL726069 | 0.95 | KDM4E (0.68) | KDM4EMAPTMAPK1RECQLTDP1 | |
| Dopamine SCHEMBL29018882 | 0.94 | KDM4E (0.69) | KDM4EMAPTMAPK1RECQLTDP1 | |
| Dopamine SCHEMBL819109 | 0.86 | KDM4E (0.68) | KDM4EMAPTMAPK1RECQLTDP1 | |
| Dopamine SCHEMBL11668670 | 0.86 | KDM4E (0.78) | KDM4EMAPTMAPK1RECQLTDP1 | |
| Dopamine SCHEMBL28320413 | 0.85 | KDM4E (0.66) | KDM4EMAPTMAPK1RECQLTDP1 | |
| Dopamine SCHEMBL3290199 | 0.84 | KDM4E (0.81) | KDM4EMAPTMAPK1RECQLTDP1 | |
| Dopamine SCHEMBL1535105 | 0.84 | KDM4E (0.88) | KDM4EMAPTMAPK1RECQLTDP1 | |
| Dopamine SCHEMBL21626214 | 0.84 | KDM4E (0.88) | KDM4EMAPTMAPK1RECQLTDP1 | |
| Dopamine SCHEMBL28199578 | 0.84 | KDM4E (0.64) | KDM4EMAPTMAPK1RECQLTDP1 | |
| Dopamine SCHEMBL28657094 | 0.82 | KDM4E (0.78) | KDM4EMAPTMAPK1RECQLTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117388422-B | Automatic aflatoxin on-line enrichment analysis device and analysis method | 广东省农业科学院农业生物基因研究中心 | 2024-03-08 | — | — | CN | disclosed |
| CN-117388422-A | Automatic aflatoxin on-line enrichment analysis device and analysis method | 广东省农业科学院农业生物基因研究中心 | 2024-01-12 | — | — | CN | disclosed |