Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dopamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.81 |
| ▸ | MAPT | P10636 | 4/20 | 0.81 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.81 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.81 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.81 |
| ▸ | DRD2 | P14416 | 2/20 | 0.81 |
| ▸ | DRD1 | P21728 | 2/20 | 0.81 |
| ▸ | DRD4 | P21917 | 2/20 | 0.81 |
| ▸ | DRD5 | P21918 | 2/20 | 0.81 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.81 |
| ▸ | DRD3 | P35462 | 2/20 | 0.81 |
| ▸ | RECQL | P46063 | 2/20 | 0.81 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.81 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.81 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.81 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.81 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.81 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.81 |
| ▸ | APEX1 | P27695 | 2/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dopamine SCHEMBL3289315 | 0.94 | KDM4E (0.78) | KDM4EMAPTMAPK1TAAR1ALDH1A1 | |
| Dopamine SCHEMBL11668670 | 0.94 | KDM4E (0.78) | KDM4EMAPTMAPK1TAAR1ALDH1A1 | |
| Dopamine SCHEMBL28657094 | 0.94 | KDM4E (0.78) | KDM4EMAPTMAPK1TAAR1ALDH1A1 | |
| Dopamine SCHEMBL29082658 | 0.91 | KDM4E (0.72) | KDM4EMAPTMAPK1TAAR1ALDH1A1 | |
| Dopamine SCHEMBL28995038 | 0.90 | KDM4E (0.84) | KDM4EMAPTMAPK1TAAR1ALDH1A1 | |
| Dopamine SCHEMBL30355306 | 0.90 | KDM4E (0.84) | KDM4EMAPTMAPK1TAAR1ALDH1A1 | |
| Dopamine SCHEMBL9051903 | 0.90 | KDM4E (0.84) | KDM4EMAPTMAPK1TAAR1ALDH1A1 | |
| Dopamine SCHEMBL27987867 | 0.90 | MAPK1 (0.91) | KDM4EMAPTMAPK1TAAR1ALDH1A1 | |
| Dopamine SCHEMBL18159501 | 0.90 | KDM4E (1.00) | KDM4EMAPTMAPK1TAAR1ALDH1A1 | |
| Dopamine SCHEMBL8505 | 0.90 | KDM4E (1.00) | KDM4EMAPTMAPK1TAAR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130030192-A1 | Method of Synthesizing Acetonide-Protected Catechol-Containing Compounds and Intermediates Produced Therein | NORTHWESTERN UNIVERSITY | 2013-01-31 | — | — | US | claimed |
| US-20100087622-A1 | Method of Synthesizing Acetonide-Protected Catechol-Containing Compounds and Intermediates Produced Therein | NORTHWESTERN UNIVERSITY (US) | 2010-04-08 | — | — | US | claimed |
| US-11325112-B2 | Method of forming inorganic nanocages | RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK (US) | 2022-05-10 | — | — | US | disclosed |
| CN-110444411-B | Conductive organic polymer coated phenolic resin matrix porous carbon composite material | 河北省科学院能源研究所 | 2021-08-17 | — | — | CN | disclosed |
| US-20200346198-A1 | METHOD OF FORMING INORGANIC NANOCAGES | RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK | 2020-11-05 | — | — | US | disclosed |
| WO-2019178547-A1 | BENZOXAZINE POLYMERS AND METHODS OF MAKING AND USING THE SAME | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2019-09-19 | — | — | WO | disclosed |
| US-20170282252-A1 | METHOD OF FORMING INORGANIC NANOCAGES | RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK | 2017-10-05 | — | — | US | disclosed |
| US-20130030192-A1 | Method of Synthesizing Acetonide-Protected Catechol-Containing Compounds and Intermediates Produced Therein | NORTHWESTERN UNIVERSITY | 2013-01-31 | — | — | US | disclosed |
| US-8227628-B2 | Method of synthesizing acetonide-protected catechol-containing compounds and intermediates produced therein | NORTHWESTERN UNIVERSITY (US) | 2012-07-24 | — | — | US | disclosed |
| US-20100087622-A1 | Method of Synthesizing Acetonide-Protected Catechol-Containing Compounds and Intermediates Produced Therein | NORTHWESTERN UNIVERSITY (US) | 2010-04-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100087622-A1 | Method of Synthesizing Acetonide-Protected Catechol-Containing Compounds and Intermediates Produced Therein | DBH, COMT, PAH | KDM4E 2054/4885MAPT 3973/4885MAPK1 2641/4885 |
| US-20130030192-A1 | Method of Synthesizing Acetonide-Protected Catechol-Containing Compounds and Intermediates Produced Therein | DBH, COMT, PAH | KDM4E 2054/4885MAPT 3973/4885MAPK1 2641/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.