Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Glutarate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 6/20 | 0.44 |
| ▸ | PPARD | Q03181 | 6/20 | 0.44 |
| ▸ | PPARA | Q07869 | 6/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.44 |
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TLR2 | O60603 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | FABP4 | P15090 | 2/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.44 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.44 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glutarate SCHEMBL29142326 | 0.94 | MEN1 (0.40) | MEN1KMT2AHSP90AA1SMN1; SMN2PPARG | |
| Glutarate SCHEMBL29142293 | 0.93 | MEN1 (0.42) | MEN1KMT2AHSP90AA1SMN1; SMN2PPARG | |
| Oxalic Acid SCHEMBL29142243 | 0.90 | HSP90AA1 (0.48) | MEN1KMT2AHSP90AA1SMN1; SMN2TSHR | |
| SCHEMBL18211771 | 0.90 | TSHR (0.40) | MEN1KMT2APPARGPPARDPPARA | |
| SCHEMBL22916707 | 0.90 | TSHR (0.40) | MEN1KMT2APPARGPPARDPPARA | |
| SCHEMBL18211781 | 0.90 | TSHR (0.40) | MEN1KMT2APPARGPPARDPPARA | |
| SCHEMBL18211773 | 0.90 | TSHR (0.40) | MEN1KMT2APPARGPPARDPPARA | |
| Succinic Acid SCHEMBL29142339 | 0.89 | MEN1 (0.43) | MEN1KMT2AHSP90AA1SMN1; SMN2PPARG | |
| Bicarbonate SCHEMBL23698462 | 0.87 | ABCB11 (0.44) | MEN1KMT2AHSP90AA1SMN1; SMN2ESR1 | |
| Bicarbonate SCHEMBL31529724 | 0.87 | ABCB11 (0.44) | MEN1KMT2AHSP90AA1SMN1; SMN2ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117440991-A | Polysiloxane composition | 默克专利有限公司 | 2024-01-23 | — | — | CN | disclosed |