Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Phthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | FABP4 | P15090 | 2/20 | 0.37 |
| ▸ | MYC | P01106 | 2/20 | 0.36 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phthalic Acid SCHEMBL29142322 | 0.93 | ALDH1A1 (0.37) | ALDH1A1ALOX15FABP4MYCNR4A1 | |
| Phthalic Acid SCHEMBL29142251 | 0.92 | TSHR (0.40) | ALDH1A1ALOX15KMT2AMEN1RECQL | |
| Phthalic Acid SCHEMBL29142329 | 0.89 | HSP90AA1 (0.45) | ALDH1A1KMT2AMEN1TSHR | |
| Phthalic Acid SCHEMBL25403187 | 0.87 | ALDH1A1 (0.44) | ALDH1A1ALOX15FABP4MYCNR4A1 | |
| Phthalic Acid SCHEMBL25403191 | 0.87 | ALDH1A1 (0.44) | ALDH1A1ALOX15FABP4MYCNR4A1 | |
| Phthalic Acid SCHEMBL29142300 | 0.87 | TSHR (0.38) | ALDH1A1ALOX15KMT2AMEN1RECQL | |
| Phthalic Acid SCHEMBL29142289 | 0.85 | TSHR (0.37) | ALDH1A1ALOX15KMT2AMEN1RECQL | |
| Phthalic Acid SCHEMBL29142295 | 0.85 | ALDH1A1 (0.37) | ALDH1A1ALOX15KMT2AMEN1RECQL | |
| Phthalic Acid SCHEMBL29142355 | 0.84 | ALDH1A1 (0.41) | ALDH1A1KMT2AMEN1TSHR | |
| Phthalic Acid SCHEMBL29142307 | 0.83 | ALDH1A1 (0.40) | ALDH1A1KMT2AMEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117440991-A | Polysiloxane composition | 默克专利有限公司 | 2024-01-23 | — | — | CN | disclosed |