Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Phthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | FABP4 | P15090 | 2/20 | 0.35 |
| ▸ | MYC | P01106 | 2/20 | 0.34 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phthalic Acid SCHEMBL29142302 | 0.93 | ALDH1A1 (0.40) | ALDH1A1ALOX15FABP4MYCNR4A1 | |
| Phthalic Acid SCHEMBL29142295 | 0.92 | ALDH1A1 (0.37) | ALDH1A1ALOX15KMT2ATSHRHTT | |
| Phthalic Acid SCHEMBL29142307 | 0.90 | ALDH1A1 (0.40) | ALDH1A1KMT2ATSHRMEN1 | |
| Phthalic Acid SCHEMBL29142344 | 0.89 | ALDH1A1 (0.39) | ALDH1A1ALOX15FABP4MYCNR4A1 | |
| Acetic Acid SCHEMBL29142366 | 0.86 | MEN1 (0.37) | KMT2AMEN1 | |
| Acetic Acid SCHEMBL14251749 | 0.86 | MEN1 (0.39) | KMT2AMEN1 | |
| Phthalic Acid SCHEMBL29142251 | 0.85 | TSHR (0.40) | ALDH1A1ALOX15KMT2ATSHRHTT | |
| Oxalic Acid SCHEMBL29142359 | 0.84 | MEN1 (0.36) | KMT2AMEN1 | |
| Phthalic Acid SCHEMBL25403191 | 0.83 | ALDH1A1 (0.44) | ALDH1A1ALOX15FABP4MYCNR4A1 | |
| Phthalic Acid SCHEMBL25403187 | 0.83 | ALDH1A1 (0.44) | ALDH1A1ALOX15FABP4MYCNR4A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117440991-A | Polysiloxane composition | 默克专利有限公司 | 2024-01-23 | — | — | CN | disclosed |