Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 8/20 | 0.50 |
| ▸ | PARP11 | Q9NR21 | 7/20 | 0.50 |
| ▸ | PARP1 | P09874 | 4/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.46 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.46 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30019687 | 1.00 | PARP10 (0.50) | PARP10PARP11PARP1TDP1MAPT | |
| SCHEMBL29698223 | 0.82 | PARP10 (0.50) | PARP10PARP11PARP1TDP1MAPT | |
| SCHEMBL27689229 | 0.80 | HTR1D (0.44) | TDP1MAPTLMNAHTTNCOA1 | |
| SCHEMBL30855765 | 0.79 | MAPT (0.44) | PARP10PARP11PARP1TDP1MAPT | |
| SCHEMBL6336167 | 0.78 | ALDH1A1 (0.46) | TDP1MAPTLMNAHTTHTR1D | |
| SCHEMBL30019767 | 0.74 | PARP10 (0.56) | PARP10PARP11PARP1MAPTLMNA | |
| SCHEMBL29144293 | 0.74 | PARP10 (0.56) | PARP10PARP11PARP1MAPTLMNA | |
| SCHEMBL426331 | 0.72 | PARP10 (0.57) | PARP10PARP11PARP1TDP1MAPT | |
| SCHEMBL27046251 | 0.72 | PARP10 (0.49) | PARP10PARP11PARP1 | |
| SCHEMBL24773896 | 0.71 | PNMT (0.56) | TDP1HTR1DHTR1BALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117242073-A | PRMT5 inhibitors and uses thereof | 海思科医药集团股份有限公司 | 2023-12-15 | — | — | CN | disclosed |
| WO-2022206964-A1 | PRMT5 INHIBITOR AND USE THEREOF | 海思科医药集团股份有限公司 | 2022-10-06 | — | — | WO | disclosed |