Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | CCR6 | P51684 | 1/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 2/20 | 0.40 |
| ▸ | RXRB | P28702 | 2/20 | 0.40 |
| ▸ | RXRG | P48443 | 2/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18154113 | 0.85 | ALDH1A1 (0.45) | ALDH1A1KMT2ATDP1MAPK1L3MBTL1 | |
| SCHEMBL189776 | 0.84 | ALDH1A1 (0.50) | ALDH1A1KMT2ATDP1MAPK1L3MBTL1 | |
| SCHEMBL29144366 | 0.79 | CCR6 (0.46) | ALDH1A1KMT2ATDP1MAPK1L3MBTL1 | |
| SCHEMBL11438372 | 0.79 | ALDH1A1 (0.44) | ALDH1A1KMT2ATDP1MAPK1L3MBTL1 | |
| SCHEMBL801192 | 0.78 | CCR6 (0.54) | ALDH1A1KMT2ATDP1MAPK1L3MBTL1 | |
| SCHEMBL7621765 | 0.78 | ALDH1A1 (0.53) | ALDH1A1KMT2ATDP1MAPK1L3MBTL1 | |
| SCHEMBL20529382 | 0.78 | ALDH1A1 (0.53) | ALDH1A1KMT2ATDP1MAPK1L3MBTL1 | |
| SCHEMBL31504010 | 0.78 | ATM (0.47) | ALDH1A1KMT2ATDP1L3MBTL1MEN1 | |
| SCHEMBL28575124 | 0.77 | ALDH1A1 (0.52) | ALDH1A1KMT2ATDP1MAPK1L3MBTL1 | |
| SCHEMBL316882 | 0.76 | ALDH1A1 (0.55) | ALDH1A1KMT2ATDP1MAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025067394-A1 | HALOGEN-SUBSTITUTED EXATECAN AMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF | 杭州爱科瑞思生物医药有限公司 | 2025-04-03 | — | — | WO | disclosed |
| CN-117417347-A | Halogen-substituted irinotecan amide derivative, preparation method and application thereof | 杭州爱科瑞思生物医药有限公司 | 2024-01-19 | — | — | CN | disclosed |