SCHEMBL2914539

SCHEMBL2914539

CC(=O)CC(=O)Nc1cc(Cl)c(NC(=O)CC(C)=O)cc1Cl

nearest known ligand 0.65

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 8/20 0.54
MEN1 O00255 4/20 0.54
KMT2A Q03164 4/20 0.54
POLB P06746 1/20 0.53
MAPT P10636 2/20 0.47
USP2 O75604 1/20 0.46
HPGD P15428 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
LMNA P02545 3/20 0.46
HTT P42858 1/20 0.46
CA1 P00915 2/20 0.44
CA2 P00918 2/20 0.44
CYP1A2 P05177 2/20 0.43
CYP2C19 P33261 2/20 0.43
KDM4E B2RXH2 1/20 0.43
HIF1A Q16665 1/20 0.43
GAA P10253 2/20 0.42
ALOX12 P18054 2/20 0.42
CYP3A4 P08684 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31570079 0.96 KMT2A (0.51) ALDH1A1MEN1KMT2APOLBMAPT
SCHEMBL11576364 0.96 KMT2A (0.51) ALDH1A1MEN1KMT2APOLBMAPT
SCHEMBL11775480 0.94 ALDH1A1 (0.50) ALDH1A1MEN1KMT2APOLBMAPT
SCHEMBL2912069 0.91 ALDH1A1 (0.48) ALDH1A1MEN1KMT2APOLBMAPT
SCHEMBL2914320 0.87 ALDH1A1 (0.67) ALDH1A1MEN1KMT2APOLBMAPT
SCHEMBL7533338 0.85 CA1 (0.48) ALDH1A1MEN1KMT2APOLBMAPT
SCHEMBL11575861 0.85 ALDH1A1 (0.49) ALDH1A1MEN1KMT2APOLBMAPT
SCHEMBL11778358 0.84 HDAC1 (0.54) ALDH1A1MEN1KMT2APOLBMAPT
SCHEMBL2904502 0.84 KDM4E (0.63) ALDH1A1MEN1KMT2AMAPTHPGD
SCHEMBL54924 0.83 MEN1 (0.80) ALDH1A1MEN1KMT2APOLBMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6756486-B1 LAKED DISAZO YELLOW PIGMENTS HAVING DESIRABLE GREEN SHADE, HEAT STABILITY, GOOD STRENGTH, BLEED RESISTANCE, MIGRATION RESISTANCE, AND LOW OR NO TOXICITY ENGELHARD CORPORATION 2004-06-29 US claimed
EP-0581245-B1 Water-insoluble azo colouring agents CLARIANT GMBH (DE) 1998-12-23 EP claimed
US-5428136-A Water-insoluble azo colorants having two azo groups and a 1,4-bis (acetoacetylamino) benzene coupling component HOECHST AG (DE) 1995-06-27 US claimed
EP-0581245-A1 Water-insoluble azo colouring agents HOECHST AKTIENGESELLSCHAFT (DE) 1994-02-02 EP claimed
US-9234256-B2 Scavenger supports and the use thereof in a process for the extraction of metals JOHNSON MATTHEY FINLAND OY (FI) 2016-01-12 US disclosed
US-9234256-B2 Scavenger supports and the use thereof in a process for the extraction of metals JOHNSON MATTHEY FINLAND OY (FI) 2016-01-12 US disclosed
US-8652335-B2 Scavenger supports and the use thereof in a process for the extraction of metals JOHNSON MATTHEY FINLAND OY (FI) 2014-02-18 US disclosed
US-8652335-B2 Scavenger supports and the use thereof in a process for the extraction of metals JOHNSON MATTHEY FINLAND OY (FI) 2014-02-18 US disclosed
US-20120211439-A1 SCAVENGER SUPPORTS AND THE USE THEREOF IN A PROCESS FOR THE EXTRACTION OF METALS JOHNSON MATTHEY FINLAND OY (FI) 2012-08-23 US disclosed
US-20120211439-A1 SCAVENGER SUPPORTS AND THE USE THEREOF IN A PROCESS FOR THE EXTRACTION OF METALS JOHNSON MATTHEY FINLAND OY (FI) 2012-08-23 US disclosed
EP-1668080-B1 NON-MIGRATING MEALLIZED DISAZO GREEN SHADE YELLOW PIGMENT ENGELHARD CORP (US) 2010-08-11 EP disclosed
US-20090023604-A1 Scavenger supports and the use thereof in a process for the extraction of metals JOHNSON MATTHEY FINLAND OY (FI) 2009-01-22 US disclosed
EP-0442846-A2 Disazo compounds with long-chain alkylester- or alkylamide moieties CIBA-GEIGY AG (CH) 1991-08-21 EP disclosed
EP-0025164-B1 DISAZO COMPOUNDS, PROCESS FOR THEIR PREPARATION AND USE HOECHST AKTIENGESELLSCHAFT (DE) 1983-04-13 EP disclosed
EP-0025164-A1 Disazo compounds, process for their preparation and use HOECHST AKTIENGESELLSCHAFT (DE) 1981-03-18 EP disclosed
US-4221709-A Azo pigments DAINICHISEIKA COLOR & CHEMICALS MFG. CO., LTD. (JP) 1980-09-09 US disclosed
US-3997521-A PIGMENTS SANDOZ LTD. (CH) 1976-12-14 US disclosed
US-3988312-A TETRAKISAZO DYES CIBA-GEIGY CORPORATION (US) 1976-10-26 US disclosed
US-3978038-A POLYAMIDES, POLYESTERS, POLYURETHANES CIBA-GEIGY CORPORATION (US) 1976-08-31 US disclosed
US-3951943-A Coupling process in the preparation of disazo diimides CHEMETRON CORPORATION (US) 1976-04-20 US disclosed