SCHEMBL2914320

SCHEMBL2914320

COc1cc(NC(=O)CC(C)=O)c(Cl)cc1NC(=O)CC(C)=O

nearest known ligand 0.83

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.67
MEN1 O00255 2/20 0.67
KMT2A Q03164 2/20 0.67
SMN1; SMN2 Q16637 2/20 0.60
HPGD P15428 1/20 0.51
MAPT P10636 1/20 0.49
POLB P06746 1/20 0.49
L3MBTL1 Q9Y468 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11575484 0.96 ALDH1A1 (0.62) ALDH1A1MEN1KMT2ASMN1; SMN2HPGD
SCHEMBL11576993 0.92 ALDH1A1 (0.68) ALDH1A1MEN1KMT2ASMN1; SMN2HPGD
SCHEMBL29466463 0.91 SMN1; SMN2 (0.73) ALDH1A1MEN1KMT2ASMN1; SMN2HPGD
SCHEMBL1118436 0.91 SMN1; SMN2 (0.73) ALDH1A1MEN1KMT2ASMN1; SMN2HPGD
SCHEMBL7130005 0.91 ALDH1A1 (0.73) ALDH1A1MEN1KMT2ASMN1; SMN2HPGD
SCHEMBL31570092 0.91 ALDH1A1 (0.73) ALDH1A1MEN1KMT2ASMN1; SMN2HPGD
SCHEMBL2914361 0.90 ALDH1A1 (0.69) ALDH1A1MEN1KMT2ASMN1; SMN2MAPT
SCHEMBL2914539 0.87 ALDH1A1 (0.54) ALDH1A1MEN1KMT2AHPGDMAPT
SCHEMBL2904502 0.85 KDM4E (0.63) ALDH1A1MEN1KMT2ASMN1; SMN2HPGD
SCHEMBL11576267 0.85 ALDH1A1 (0.65) ALDH1A1MEN1KMT2ASMN1; SMN2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6756486-B1 LAKED DISAZO YELLOW PIGMENTS HAVING DESIRABLE GREEN SHADE, HEAT STABILITY, GOOD STRENGTH, BLEED RESISTANCE, MIGRATION RESISTANCE, AND LOW OR NO TOXICITY ENGELHARD CORPORATION 2004-06-29 US claimed
EP-1668080-B1 NON-MIGRATING MEALLIZED DISAZO GREEN SHADE YELLOW PIGMENT ENGELHARD CORP (US) 2010-08-11 EP disclosed
US-7262284-B2 Method for producing disazo pigments CLARIANT PRODUKTE (DEUTSCHLAND) GMBH (DE) 2007-08-28 US disclosed
US-20070066724-A1 Bisazoquinolone pigments, processes for their preparation and their use BENKHOFF JOHANNES 2007-03-22 US disclosed
US-20060167236-A1 Method for producing disazo pigments CLARIANT GMBH (DE) 2006-07-27 US disclosed
EP-1668080-A1 NON-MIGRATING MEALLIZED DISAZO GREEN SHADE YELLOW PIGMENT Engelhard Corporation (US) 2006-06-14 EP disclosed
EP-1633817-A1 BISAZOQUINOLONE PIGMENTS, PROCESSES FOR THEIR PREPARATION AND THEIR USE Ciba SC Holding AG (CH) 2006-03-15 EP disclosed
WO-2005033212-A1 NON-MIGRATING MEALLIZED DISAZO GREEN SHADE YELLOW PIGMENT ENGELHARD CORPORATION (US) 2005-04-14 WO disclosed
EP-1517962-A1 METHOD FOR PRODUCING DISAZO PIGMENTS Clariant GmbH (DE) 2005-03-30 EP disclosed
WO-2004111134-A1 BISAZOQUINOLONE PIGMENTS, PROCESSES FOR THEIR PREPARATION AND THEIR USE CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2004-12-23 WO disclosed
EP-0581245-B1 Water-insoluble azo colouring agents CLARIANT GMBH (DE) 1998-12-23 EP disclosed
EP-0585873-B1 Method of preparing disazo pigments CLARIANT GMBH (DE) 1997-12-29 EP disclosed
US-5559216-A AZO COUPLING HOECHST AG (DE) 1996-09-24 US disclosed
US-5428136-A Water-insoluble azo colorants having two azo groups and a 1,4-bis (acetoacetylamino) benzene coupling component HOECHST AG (DE) 1995-06-27 US disclosed
EP-0585873-A1 Method of preparing disazo pigments HOECHST AKTIENGESELLSCHAFT (DE) 1994-03-09 EP disclosed
EP-0581245-A1 Water-insoluble azo colouring agents HOECHST AKTIENGESELLSCHAFT (DE) 1994-02-02 EP disclosed
EP-0025164-B1 DISAZO COMPOUNDS, PROCESS FOR THEIR PREPARATION AND USE HOECHST AKTIENGESELLSCHAFT (DE) 1983-04-13 EP disclosed
EP-0025164-A1 Disazo compounds, process for their preparation and use HOECHST AKTIENGESELLSCHAFT (DE) 1981-03-18 EP disclosed
US-4221709-A Azo pigments DAINICHISEIKA COLOR & CHEMICALS MFG. CO., LTD. (JP) 1980-09-09 US disclosed
US-4070353-A FOR PLASTICS AND PRINTING INKS, YELLOW TO ORANGE SHADES CIBA-GEIGY CORPORATION (US) 1978-01-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070066724-A1 Bisazoquinolone pigments, processes for their preparation and their use NR2E3, NR4A3, NR4A1 ALDH1A1 3399/4885MEN1 3514/4885KMT2A 3520/4885
US-20060167236-A1 Method for producing disazo pigments TYR, IPO4, CBR3 ALDH1A1 560/4885MEN1 2054/4885KMT2A 2138/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.