Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 12/20 | 1.00 |
| ▸ | DRD1 | P21728 | 3/20 | 1.00 |
| ▸ | DRD4 | P21917 | 3/20 | 1.00 |
| ▸ | DRD5 | P21918 | 3/20 | 1.00 |
| ▸ | DRD3 | P35462 | 3/20 | 1.00 |
| ▸ | HTR1A | P08908 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.61 |
| ▸ | HTR2A | P28223 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.61 |
| ▸ | HRH1 | P35367 | 1/20 | 0.61 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Skf-89124A SCHEMBL7382070 | 0.99 | DRD2 (0.97) | DRD2DRD1DRD4DRD5DRD3 | |
| Hydrochloric Acid SCHEMBL7374216 | 0.94 | DRD2 (0.88) | DRD2DRD1DRD4DRD5DRD3 | |
| SCHEMBL10921043 | 0.82 | DRD2 (0.70) | DRD2DRD1DRD4DRD5DRD3 | |
| SCHEMBL10920726 | 0.82 | DRD2 (0.70) | DRD2DRD1DRD4DRD5DRD3 | |
| Hydrochloric Acid SCHEMBL7379885 | 0.81 | DRD2 (0.68) | DRD2DRD1DRD4DRD5DRD3 | |
| Bromide SCHEMBL10920638 | 0.81 | DRD2 (0.68) | DRD2DRD1DRD4DRD5DRD3 | |
| Bromide SCHEMBL10919553 | 0.81 | DRD2 (0.68) | DRD2DRD1DRD4DRD5DRD3 | |
| Bromide SCHEMBL7380398 | 0.79 | DRD2 (0.65) | DRD2DRD1DRD4DRD5DRD3 | |
| SCHEMBL7383689 | 0.79 | DRD2 (0.65) | DRD2DRD1DRD4DRD5DRD3 | |
| Bromide SCHEMBL7384529 | 0.78 | DRD2 (0.64) | DRD2DRD1DRD4DRD5DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0046666-B1 | 2(3H)-INDOLONES, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM | SMITHKLINE BECKMAN CORPORATION (US) | 1986-04-23 | — | — | EP | claimed |
| US-4414224-A | 4-AMINO OR SUBSTITUTED AMINO-7-HYDROXY-2-(3H)-INDOLONES | SMITHKLINE BECKMAN CORPORATION (US) | 1983-11-08 | — | — | US | claimed |
| EP-0046666-A1 | 2(3H)-indolones, process for their preparation and compositions containing them | SMITHKLINE BECKMAN CORPORATION (US) | 1982-03-03 | — | — | EP | claimed |
| US-4314944-A | CARDIOVASCULAR DISORDERS, HYPOTENSIVE AGENTS | SMITHKLINE CORPORATION (US) | 1982-02-09 | — | — | US | claimed |
| EP-1385857-B1 | PHARMACEUTICAL DOPAMINE GLYCOCONJUGATE COMPOSITIONS AND METHODS OF THEIR PREPARATION | INTERNAT MEDICAL INNOVATIONS I (US) | 2010-08-25 | — | — | EP | disclosed |
| US-7378439-B2 | Process for the preparation of 4-(2-dipropylaminoethyl)-1,3-dihydro-2H-indol-2-one hydrochloride | USV, LTD. (IN) | 2008-05-27 | — | — | US | disclosed |
| US-7378439-B2 | Process for the preparation of 4-(2-dipropylaminoethyl)-1,3-dihydro-2H-indol-2-one hydrochloride | USV, LTD. (IN) | 2008-05-27 | — | — | US | disclosed |
| US-20060189547-A1 | Novel pharmaceutical agents containing carbohydrate moieties and methods of their preparation and use | CHRISTIAN SAMUEL T | 2006-08-24 | — | — | US | disclosed |
| US-20030119761-A1 | Novel pharmaceutical agents containing carbohydrate moieties and methods of their preparation and use | CHRISTIAN SAMUEL T (US) | 2003-06-26 | — | — | US | disclosed |
| US-4663482-A | Intermediates for preparing 7-(2-aminoethyl)-1,3-benzthia- or oxa- zol-2(3H)-ones | SMITHKLINE BECKMAN CORPORATION (US) | 1987-05-05 | — | — | US | disclosed |
| EP-0046666-B1 | 2(3H)-INDOLONES, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM | SMITHKLINE BECKMAN CORPORATION (US) | 1986-04-23 | — | — | EP | disclosed |
| EP-0174811-A2 | 7-(2-aminoethyl)-1,3-Benzthia- or oxa- zol-2(3H) -ones | SMITHKLINE BECKMAN CORPORATION (US) | 1986-03-19 | — | — | EP | disclosed |
| US-4554284-A | 7-(2-Aminoethyl)-1,3-benzthia- or oxa-zol-2(3H)-ones | SMITHKLINE BECKMAN CORPORATION (US) | 1985-11-19 | — | — | US | disclosed |
| US-4414224-A | 4-AMINO OR SUBSTITUTED AMINO-7-HYDROXY-2-(3H)-INDOLONES | SMITHKLINE BECKMAN CORPORATION (US) | 1983-11-08 | — | — | US | disclosed |
| US-4414224-A | 4-AMINO OR SUBSTITUTED AMINO-7-HYDROXY-2-(3H)-INDOLONES | SMITHKLINE BECKMAN CORPORATION (US) | 1983-11-08 | — | — | US | disclosed |
| EP-0046666-A1 | 2(3H)-indolones, process for their preparation and compositions containing them | SMITHKLINE BECKMAN CORPORATION (US) | 1982-03-03 | — | — | EP | disclosed |
| EP-0046666-A1 | 2(3H)-indolones, process for their preparation and compositions containing them | SMITHKLINE BECKMAN CORPORATION (US) | 1982-03-03 | — | — | EP | disclosed |
| US-4314944-A | CARDIOVASCULAR DISORDERS, HYPOTENSIVE AGENTS | SMITHKLINE CORPORATION (US) | 1982-02-09 | — | — | US | disclosed |
| US-4314944-A | CARDIOVASCULAR DISORDERS, HYPOTENSIVE AGENTS | SMITHKLINE CORPORATION (US) | 1982-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030119761-A1 | Novel pharmaceutical agents containing carbohydrate moieties and methods of their preparation and use | CSGALNACT1, DDOST, STT3B | DRD2 694/4885DRD1 711/4885DRD4 729/4885 |
| US-20060189547-A1 | Novel pharmaceutical agents containing carbohydrate moieties and methods of their preparation and use | CSGALNACT1, DDOST, STT3B | DRD2 694/4885DRD1 711/4885DRD4 729/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.