SCHEMBL2914855

SCHEMBL2914855

Cc1cc(C2=NC(C)(C)C(C)(C)c3c(F)cccc32)cnc1C

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 1/20 0.35
IL2 P60568 1/20 0.34
FEN1 P39748 4/20 0.33
ALOX5AP P20292 3/20 0.33
VRK1 Q99986 1/20 0.33
STIM1 Q13586 3/20 0.32
ORAI1 Q96D31 3/20 0.32
PDK2 Q15119 1/20 0.32
MBNL1 Q9NR56 1/20 0.31
GRIN2B Q13224 2/20 0.31
CYP1A2 P05177 1/20 0.31
CYP2C9 P11712 1/20 0.31
CYP2C19 P33261 1/20 0.31
GRIN1 Q05586 1/20 0.31
KCNH2 Q12809 1/20 0.31
CYP11B1 P15538 1/20 0.31
CYP11B2 P19099 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
CASP3 P42574 1/20 0.31
SENP8 Q96LD8 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21061329 0.90 IL2 (0.35) CYP2A6IL2FEN1ALOX5APVRK1
SCHEMBL4416025 0.84 MGAM (0.36) FEN1ALOX5APMBNL1GRIN2BNPC1
SCHEMBL29919696 0.84 MGAM (0.36) FEN1ALOX5APMBNL1GRIN2BNPC1
SCHEMBL29432957 0.82 ABCB1 (0.39) FEN1ALOX5APMBNL1GRIN2BL3MBTL1
SCHEMBL4412921 0.82 ABCB1 (0.39) FEN1ALOX5APMBNL1GRIN2BL3MBTL1
SCHEMBL318061 0.82 AKR1C3 (0.41) CYP2A6MBNL1CYP1A2NPC1
SCHEMBL29352004 0.82 AKR1C3 (0.41) CYP2A6MBNL1CYP1A2NPC1
SCHEMBL31290758 0.82 CYP2A6 (0.35) CYP2A6IL2FEN1ALOX5APPDK2
Hydrochloric Acid SCHEMBL4531372 0.81 AKR1C3 (0.41) CYP2A6MBNL1CYP1A2NPC1
SCHEMBL4507256 0.80 L3MBTL1 (0.39) L3MBTL1CASP3SENP8SENP7SENP6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2223919-B1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND THEIR USE AS AGRICULTURAL AND HORTICULTURAL FUNGICIDES NIPPON SODA CO (JP) 2014-10-15 EP disclosed
EP-2223919-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND BACTERICIDE FOR AGRICULTURAL AND HORTICULTURAL USE Nippon Soda Co., Ltd. (JP) 2010-09-01 EP disclosed