Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 5/20 | 0.52 |
| ▸ | CA2 | P00918 | 5/20 | 0.52 |
| ▸ | CA9 | Q16790 | 5/20 | 0.52 |
| ▸ | CA12 | O43570 | 4/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31074738 | 0.83 | LMNA (0.44) | LMNAMAPK1ALDH1A1THRBTSHR | |
| SCHEMBL31074685 | 0.82 | LMNA (0.39) | LMNAMAPK1ALDH1A1THRBTSHR | |
| SCHEMBL31074705 | 0.80 | GLA (0.45) | LMNAMAPK1ALDH1A1THRBTSHR | |
| SCHEMBL31018736 | 0.78 | LMNA (0.54) | LMNAMAPK1ALDH1A1THRBTSHR | |
| SCHEMBL16828763 | 0.75 | DGAT1 (0.41) | LMNACA1CA2CA9CA12 | |
| SCHEMBL29149917 | 0.75 | DGAT1 (0.36) | LMNACA1CA2CA9CA12 | |
| SCHEMBL1485742 | 0.75 | DGAT1 (0.36) | — | |
| SCHEMBL4631185 | 0.74 | DGAT1 (0.34) | — | |
| SCHEMBL31018735 | 0.74 | CA1 (0.65) | LMNAMAPK1ALDH1A1THRBTSHR | |
| SCHEMBL31324233 | 0.74 | DGAT1 (0.35) | LMNAMAPK1ALDH1A1THRBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117177970-A | Polycyclic derivative regulator, preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2023-12-05 | — | — | CN | disclosed |
| WO-2022228490-A1 | POLYCYCLIC DERIVATIVE MODULATOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 上海翰森生物医药科技有限公司 | 2022-11-03 | — | — | WO | disclosed |