SCHEMBL29150321

SCHEMBL29150321

COc1ccccc1NC(=O)CCSC(F)(F)F

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.72
POLB P06746 2/20 0.72
LMNA P02545 2/20 0.62
CASP3 P42574 1/20 0.62
SENP8 Q96LD8 1/20 0.62
SENP7 Q9BQF6 1/20 0.62
SENP6 Q9GZR1 1/20 0.62
HTT P42858 1/20 0.56
HDAC3 O15379 1/20 0.56
HDAC4 P56524 1/20 0.56
HDAC1 Q13547 1/20 0.56
HDAC7 Q8WUI4 1/20 0.56
HDAC2 Q92769 1/20 0.56
HDAC10 Q969S8 1/20 0.56
HDAC11 Q96DB2 1/20 0.56
HDAC8 Q9BY41 1/20 0.56
HDAC6 Q9UBN7 1/20 0.56
HDAC9 Q9UKV0 1/20 0.56
HDAC5 Q9UQL6 1/20 0.56
NPSR1 Q6W5P4 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13233264 0.80 ALDH1A1 (0.67) ALDH1A1POLBLMNACASP3SENP8
SCHEMBL28518484 0.79 GLA (0.71) ALDH1A1POLBLMNAHTTHDAC3
SCHEMBL30738420 0.78 ALDH1A1 (0.72) ALDH1A1POLBLMNAHTTHDAC3
SCHEMBL31512566 0.78 ALDH1A1 (0.63) ALDH1A1POLBLMNAHTTHDAC3
SCHEMBL5183678 0.78 ALDH1A1 (0.72) ALDH1A1POLBLMNAHTTHDAC3
SCHEMBL23080145 0.78 ALDH1A1 (0.72) ALDH1A1POLBLMNACASP3SENP8
SCHEMBL2007035 0.77 MEN1 (0.76) ALDH1A1POLBLMNAHTTHDAC3
SCHEMBL7370783 0.77 HDAC3 (0.70) ALDH1A1POLBHTTHDAC3HDAC4
SCHEMBL24715738 0.77 MEN1 (0.62) ALDH1A1POLBLMNAHTTHDAC3
SCHEMBL7181212 0.77 ALDH1A1 (0.70) ALDH1A1POLBLMNACASP3SENP8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117466789-A Synthesis method of beta-trifluoromethylthioamide participated by silver trifluormethane 陕西先氟领创科技有限公司 2024-01-30 CN disclosed