Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 4/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.40 |
| ▸ | GCK | P35557 | 2/20 | 0.39 |
| ▸ | TRPC6 | Q9Y210 | 3/20 | 0.38 |
| ▸ | GCKR | Q14397 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.36 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13779836 | 0.84 | MAPT (0.50) | CHRNB2CHRNA4GCKMAPTPIK3CA | |
| SCHEMBL29883782 | 0.84 | MAPT (0.50) | CHRNB2CHRNA4GCKMAPTPIK3CA | |
| SCHEMBL3367822 | 0.84 | CHRNB2 (0.47) | CHRNB2CHRNA4GCKTRPC6GCKR | |
| SCHEMBL29353249 | 0.82 | MAPT (0.53) | CHRNB2CHRNA4GCKMAPTKDM4E | |
| SCHEMBL823334 | 0.82 | MAPT (0.53) | CHRNB2CHRNA4GCKMAPTKDM4E | |
| SCHEMBL28829278 | 0.82 | CHRNB2 (0.42) | CHRNB2CHRNA4GCKTRPC6GCKR | |
| SCHEMBL18053899 | 0.81 | PIK3CA (0.42) | CHRNB2CHRNA4GCKTRPC6GCKR | |
| SCHEMBL22112923 | 0.80 | KDM4E (0.47) | CHRNB2CHRNA4GCKTRPC6GCKR | |
| SCHEMBL521049 | 0.79 | PIK3CA (0.56) | MAPTPIK3R1PIK3CAMTORDHFR | |
| SCHEMBL521324 | 0.79 | MAPT (0.58) | MAPTPIK3CAMTORKDM4ERPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117295737-A | HPK1 antagonists and uses thereof | 林伯士萨顿公司 | 2023-12-26 | — | — | CN | disclosed |