SCHEMBL29152141

SCHEMBL29152141

N#Cc1c2ccccc2c(-c2cccc(F)c2)c2ccccc12

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA1 P30542 3/20 0.50
ADORA2B P29275 2/20 0.50
ADORA2A P29274 2/20 0.50
KDM4E B2RXH2 2/20 0.49
HPGD P15428 2/20 0.49
NPSR1 Q6W5P4 1/20 0.49
RXFP1 Q9HBX9 1/20 0.49
IDO1 P14902 1/20 0.47
NRP1 O14786 1/20 0.41
GRIA2 P42262 1/20 0.39
GRIA4 P48058 1/20 0.39
ALDH1A1 P00352 1/20 0.39
MAP4K4 O95819 1/20 0.39
GABRG2 P18507 2/20 0.39
GABRB3 P28472 2/20 0.39
GABRA5 P31644 2/20 0.39
GABRA3 P34903 2/20 0.39
LMNA P02545 1/20 0.39
GABRP O00591 1/20 0.39
GABRD O14764 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14565328 0.86 ADORA2A (0.41) ADORA1ADORA2BADORA2AKDM4EHPGD
SCHEMBL12125684 0.85 TAAR1 (0.48) ADORA2AHPGDIDO1MAP4K4GABRG2
SCHEMBL29152145 0.80 ADORA1 (0.46) ADORA1ADORA2BADORA2AKDM4EHPGD
SCHEMBL29152133 0.80 CTSS (0.50) ADORA1KDM4ENPSR1ALDH1A1LMNA
SCHEMBL29152143 0.79 ADORA1 (0.48) ADORA1ADORA2BADORA2AKDM4EHPGD
SCHEMBL29152138 0.79 KDM4E (0.44) ADORA1ADORA2AKDM4EHPGDRXFP1
SCHEMBL30662431 0.79 IDO1 (0.45) ADORA1ADORA2AKDM4EIDO1ALDH1A1
SCHEMBL29152127 0.79 ALDH1A1 (0.54) ADORA1ADORA2AKDM4EHPGDIDO1
SCHEMBL16383984 0.79 ADORA1 (0.47) ADORA1ADORA2BADORA2AKDM4EHPGD
SCHEMBL24927805 0.74 MAP4K4 (0.44) ADORA1ADORA2BADORA2AKDM4EHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117164478-A Method for preparing anthracycline derivative 苏州大学 2023-12-05 CN disclosed