Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 5/20 | 0.59 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.57 |
| ▸ | INSR | P06213 | 3/20 | 0.57 |
| ▸ | MET | P08581 | 4/20 | 0.55 |
| ▸ | MAP4K1 | Q92918 | 5/20 | 0.54 |
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.49 |
| ▸ | JAK2 | O60674 | 2/20 | 0.49 |
| ▸ | KDR | P35968 | 2/20 | 0.49 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.49 |
| ▸ | CDC7 | O00311 | 1/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.49 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.49 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.49 |
| ▸ | PAK4 | O96013 | 1/20 | 0.49 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL885243 | 0.96 | PTK2 (0.63) | PTK2ALKINSRMETMAP4K1 | |
| SCHEMBL884998 | 0.88 | ALK (0.69) | PTK2ALKINSRMETMAP4K1 | |
| SCHEMBL2060956 | 0.86 | LRRK2 (0.49) | MAP4K1LRRK2 | |
| SCHEMBL885007 | 0.86 | ULK1 (0.62) | PTK2ALKINSRMETMAP4K1 | |
| SCHEMBL885002 | 0.86 | MAP4K1 (0.68) | PTK2ALKINSRMETMAP4K1 | |
| SCHEMBL2062394 | 0.83 | LRRK2 (0.49) | MAP4K1LRRK2 | |
| SCHEMBL884869 | 0.83 | ULK1 (0.62) | PTK2ALKINSRMETMAP4K1 | |
| SCHEMBL885348 | 0.78 | ALK (0.56) | ALKINSRMETMAP4K1LRRK2 | |
| SCHEMBL886108 | 0.78 | ULK1 (0.62) | PTK2ALKINSREGFRULK1 | |
| SCHEMBL885095 | 0.76 | MET (0.78) | PTK2ALKINSRMETPTK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |